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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.97 No.1
- 발행연도
- 2019.7
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Purpose: The combination of indocyanine green and methylene blue (ICG + MB) was reported to be an efficient tracer method in sentinel lymph node biopsy (SLNB). However, whether this method is superior to MB only or carbon nanoparticles (CN) is controversial. This study was to evaluate the efficacy of the three methods in SLNB for breast cancer, and to analyze its influencing factors.
Methods: One hundred eighty patients with early breast cancer were recruited and randomly divided into 3 groups. Each group comprising of 60 patients with SLNB using ICG + MB, MB, and CN, respectively. Then the 3 groups were compared in detection rate, mean number of SLNs, and the detection rates and number of metastatic sentinel lymph nodes (SLNs).
Results: The detection rate of SLNs was 100% (60 of 60) in ICG + MB group, 96.7% (58 of 60), and 98.3% (59 of 60) in MB and CN group, respectively, with no significant difference (P = 0.362). Totally, 204 SLNs (mean ± standard deviation [SD] [range], 3.4 ± 1.4 [2–8]) were detected in ICG + MB group, 102 (1.7 ± 0.7 [0–3]) and 145 (2.4 ± 0.7 [0–6]) in MB and CN group, indicating significant difference (P < 0.001). The detection rate of metastatic SLN was 23.3% (14 of 60) in ICG + MB group, which was higher than 18.3% (11 of 60) and 20% (11 of 60) in MB and CN group, respectively, but showed no statistical significance (P = 0.788).
Conclusion: ICG + MB method was superior to MB only and CN only methods in the mean number of SLNs, thus predicting axillary lymph node metastasis more accurately. Therefore, in areas where the standard method is not available, ICG + MB may be more suitable as an alternative tracer for SLNB.
Methods: One hundred eighty patients with early breast cancer were recruited and randomly divided into 3 groups. Each group comprising of 60 patients with SLNB using ICG + MB, MB, and CN, respectively. Then the 3 groups were compared in detection rate, mean number of SLNs, and the detection rates and number of metastatic sentinel lymph nodes (SLNs).
Results: The detection rate of SLNs was 100% (60 of 60) in ICG + MB group, 96.7% (58 of 60), and 98.3% (59 of 60) in MB and CN group, respectively, with no significant difference (P = 0.362). Totally, 204 SLNs (mean ± standard deviation [SD] [range], 3.4 ± 1.4 [2–8]) were detected in ICG + MB group, 102 (1.7 ± 0.7 [0–3]) and 145 (2.4 ± 0.7 [0–6]) in MB and CN group, indicating significant difference (P < 0.001). The detection rate of metastatic SLN was 23.3% (14 of 60) in ICG + MB group, which was higher than 18.3% (11 of 60) and 20% (11 of 60) in MB and CN group, respectively, but showed no statistical significance (P = 0.788).
Conclusion: ICG + MB method was superior to MB only and CN only methods in the mean number of SLNs, thus predicting axillary lymph node metastasis more accurately. Therefore, in areas where the standard method is not available, ICG + MB may be more suitable as an alternative tracer for SLNB.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Goldhirsch A / 2007 / Progress and promise : highlights of the international expert consensus on the primary therapy of early breast cancer 2007 / Ann Oncol 18:1133~1144
박세현 / 2017 / Feasibility of sentinel lymph node dissection using Tc-99m phytate in papillary thyroid carcinoma / 대한외과학회지 93(5):240~245
오승엽 / 2014 / Clinical application of sentinel lymph node mapping in colon cancer: in vivo vs. ex vivo techniques / 대한외과학회지 87(3):118~122
Lyman GH / 2017 / Sentinel lymph node biopsy for patients with early-stage breast cancer : 2016American Society of Clinical Oncology Clinical Practice Guideline Update Summary / J Oncol Pract 13:196~198
van der Vorst JR / 2012 / Randomized comparison of nearinfrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients / Ann Surg Oncol 19:4104~4111
박세현 / 2017 / Feasibility of sentinel lymph node dissection using Tc-99m phytate in papillary thyroid carcinoma / 대한외과학회지 93(5):240~245
오승엽 / 2014 / Clinical application of sentinel lymph node mapping in colon cancer: in vivo vs. ex vivo techniques / 대한외과학회지 87(3):118~122
Lyman GH / 2017 / Sentinel lymph node biopsy for patients with early-stage breast cancer : 2016American Society of Clinical Oncology Clinical Practice Guideline Update Summary / J Oncol Pract 13:196~198
van der Vorst JR / 2012 / Randomized comparison of nearinfrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients / Ann Surg Oncol 19:4104~4111
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UCI(KEPA) : I410-ECN-0101-2019-514-000899738