지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose: This study was conducted to collect and analyze real world data to evaluate the effectiveness and safety of comprehensive traditional Korean Medicine treatment on quality of life, anorexia and cachexia of cancer patients.
Methods: We analyzed medical records of 62 cancer patients admitted to O-I Dang Korean Medicine Hospital from February 2018 to February 2019. The primary outcome was a change score in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary outcomes were Functional Assessment of Cancer Therapy-General (FACT-G), Trial Outcome Index(TOI) of FAACT, 11 point Pain Intensity Numeric Rating Score (11 PI-NRS) and Patient Global Impression of Change (PGIC) and adverse event.
Results: Cachexia and quality of life in cancer patients assessed by FAACT, increased by 5.59±14.83 (p=0.004) after treatment. PI-NRS was reduced by 2.10±1.81 (p<0.001) and TOI and FACT-G total scores were increased by 5.17±11.70 (p=0.001) and 3.59±10.94 (p=0.012), respectively. These results were also clinically meaningful assessed via minimal clinically important difference (MCID). There was no severe adverse event.
Conclusion: These findings suggest that comprehensive traditional Korean Medicine treatment might be effective and safe strategy for improving quality of life, anorexia, cachexia and pain of cancer patients. Further advanced studies with controlled group and more participants with rigorous design are needed to ensure these findings.
Methods: We analyzed medical records of 62 cancer patients admitted to O-I Dang Korean Medicine Hospital from February 2018 to February 2019. The primary outcome was a change score in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary outcomes were Functional Assessment of Cancer Therapy-General (FACT-G), Trial Outcome Index(TOI) of FAACT, 11 point Pain Intensity Numeric Rating Score (11 PI-NRS) and Patient Global Impression of Change (PGIC) and adverse event.
Results: Cachexia and quality of life in cancer patients assessed by FAACT, increased by 5.59±14.83 (p=0.004) after treatment. PI-NRS was reduced by 2.10±1.81 (p<0.001) and TOI and FACT-G total scores were increased by 5.17±11.70 (p=0.001) and 3.59±10.94 (p=0.012), respectively. These results were also clinically meaningful assessed via minimal clinically important difference (MCID). There was no severe adverse event.
Conclusion: These findings suggest that comprehensive traditional Korean Medicine treatment might be effective and safe strategy for improving quality of life, anorexia, cachexia and pain of cancer patients. Further advanced studies with controlled group and more participants with rigorous design are needed to ensure these findings.
목차
서론
연구방법
결과
고찰
결론
참고문헌
참고문헌 (48)
참고문헌 신청
Lagman RL / 2005 / Common Symptoms in Advanced Cancer / Surg Clin North Am 85(2):237~255
Mantovani G / 2001 / Managing Cancer-Related Anorexia/Cachexia / Drugs 61(4):499~514
Wie G-A / 2010 / Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea / Nutr Burbank Los Angel Cty Calif 26(3):263~268
Brierley DI / 2019 / Chemotherapy -induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol / J Cachexia Sarcopenia Muscle
Lis CG / 2009 / Can anorexia predict patient satisfaction with quality of life in advanced cancer? / Support Care Cancer Off J Multinatl Assoc Support Care Cancer 17(2):129~135
Mantovani G / 2001 / Managing Cancer-Related Anorexia/Cachexia / Drugs 61(4):499~514
Wie G-A / 2010 / Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea / Nutr Burbank Los Angel Cty Calif 26(3):263~268
Brierley DI / 2019 / Chemotherapy -induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol / J Cachexia Sarcopenia Muscle
Lis CG / 2009 / Can anorexia predict patient satisfaction with quality of life in advanced cancer? / Support Care Cancer Off J Multinatl Assoc Support Care Cancer 17(2):129~135
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UCI(KEPA) : I410-ECN-0101-2019-519-000946620