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Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts
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추출용매에 따른 황금 추출물의 항산화 활성 및 암세포 증식 억제 효과

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Type
Academic journal
Author
Mi Jeong Lim (대구가톨릭대학교) Yul Ri Gu (대구가톨릭대학교) Joo-Heon Hong (대구가톨릭대학교)
Journal
The Korean Society of Food Preservation Food Science and Preservation Vo.26 No.5 KCI Accredited Journals SCOPUS
Published
2019.8
Pages
566 - 575 (10page)
DOI
10.11002/kjfp.2019.26.5.566

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Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts
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This study was conducted to examine the antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts based on extraction solvent. The yield by hot water extraction (42.56%) was higher than those by extraction with 80% ethanol (19.47%) and 80% methanol (19.57%). The total phenolic and total flavonoid contents in the methanol extract were 26.44 g/100 g and 4.23 g/100 g, respectively. The oxygen radical absorbance capacity of the methanol extract (100 μg/mL) was 274.23 μM, which was significantly higher than those of the other extracts. The DPPH and ABTS radical scavenging activities of the methanol extract (1,000 μg/mL) were 88.71% and 85.05% respectively, while the ferric reducing antioxidant power and reducing power were 110.14 μM and 1.01 respectively. The protective effects against oxidative stress in L132 cells imparted by the methanol extract was better than those imparted by the other extracts. The production of nitric oxide in the methanol extract decreased in a dose-dependent manner. The antitumor activities of the methanol extract (500 μg/mL) in SNU719, A549 and HT29 was cell lines were 75.99%, 61.43% and 67.01% respectively. This study suggests that Scutellaria baicalensis extracts may be useful functional components.
#Scutellaria baicalensis #methanol extract #antioxidant activities #nitric oxide #inhibitory effects of cancer cells

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References (45)

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Menrad K / 2003 / Market and marketing of functional food in europe / J Food Eng 56:181~188 google schola Frudovich I / 1978 / The biology of oxygen radicals / Science 201:875~880 google schola Kim SI / 1997 / Antioxidative effects of Scutellariae radix aaquaacupuncture solution on lipid preoxidation induced by free radicals / Kor J Oriental Preventive Medical Society 1:48~54 google schola 장세주 / 2015 / 백출, 어성초, 금은화, 황금, 황련과 Metformin의 병용 투여 시 항산화 효과 및 전지방세포 분화 억제 효과 / 한방비만학회지 15(1):24~32 dbpia 지흥숙 / 2005 / 목초액의 항산화 및 항염증 활성 google schola

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UCI(KEPA) : I410-ECN-0101-2019-059-000988152