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To reduce the caregiver burden, there is a need to understand caregiver risk in caring for patients with dementia and factors related to the risk. The purposes of this study are to examine comprehensive caregiving risk of family caregivers for patients with dementia and to investigate associations between characteristics of family caregivers and caregiver risk. Family caregivers from dementia centers in a metropolitan city were assessed and 220 samples were used for data analysis. Risk appraisal, personality, and characteristics of family caregivers were measured using self-administered questionnaires. Descriptive statistics and hierarchical multiple regression analyses were conducted. The burden on caregiving skill was the highest risk and safety was the lowest risk. Significant factors of overall risk were subjective health, certified care worker, and monthly income. Neurotic personality was one of main factors that attribute to caregiver risk. Based on the comprehensive assessment of caregiver risk and the related factors, this study suggests that family caregiver’s characteristics can influence caregiver risk differently and individually tailored support with a family-centered approach is beneficial for family caregivers.

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