지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Purpose: Aspiration pneumonia is an important complication of drug intoxication with decreased mental status. The purpose of the study is to investigate the risk factors of aspiration pneumonia in the patients of benzodiazepine overdose with or without co-ingestion of other drugs.
Methods: A retrospective chart review of patients who visited the emergency department between January 2012 and December 2014 was conducted. Demographic data, time from ingestion to visit, initial vital signs, symptoms, mental status, medical history, laboratory results, chest radiological findings and co-ingested medications were recorded. Multiple logistic analyses were performed to verify the association between variables and the development of aspiration pneumonia.
Results: A total of 249 patients presented to the emergency department with benzodiazepine overdose. Aspiration pneumonia had developed in 24 patients (9.6%). Univariate analysis revealed time from ingestion to visit was longer, Glasgow coma scale score was lower, hypoxia was presented, leukocytosis was shown, types of ingested drugs was high, less activated charcoal was applied and tricyclic antidepressants was taken in patients that developed aspiration pneumonia. Time from ingestion to visit (odds ratio (OR) 1.121, 95% confidence interval (CI), 1.057- 1.189, p=0.000), GCS score (OR 0.724. 95% CI, 0.624-0.839, p=0.000), oxygen saturation (OR 0.895, 95% CI, 0.835-0.959, p=0.002), and co-ingestion of TCA (OR 4.595, 95% CI, 1.169-18.063, p=0.029) were identified as risk factors of morbidity of aspiration pneumonia upon multiple logistic regression analysis.
Conclusion: Time from ingestion to visit, low GCS score, low oxygen saturation and co-ingestion of TCA were risk factors of the development of aspiration pneumonia in benzodiazepine overdose patients.
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참고문헌 (15)
참고문헌 신청
Bachhuber MA / 2016 / Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013 / Am J Public Health 106:686~688
Narstaran EM / 2009 / Comparative Evaluation of Glasgow Coma Score and Gag Reflex in Predicting Aspiration Pneumonitis in Acute Poisoning / J Critical Care 24:470.9~415
Eddleston M / 2000 / Patterns and problems of deliberate self-poisoning in the developing world / QJM 93:715~731
Christ A / 2006 / Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients / Intensive Care Med 32:1423~1427
Isbister GK / 2004 / Aspiration pneumonitis in an overdose population:frequency, predictors, and outcomes / Crit Care Med 32:88~93
Narstaran EM / 2009 / Comparative Evaluation of Glasgow Coma Score and Gag Reflex in Predicting Aspiration Pneumonitis in Acute Poisoning / J Critical Care 24:470.9~415
Eddleston M / 2000 / Patterns and problems of deliberate self-poisoning in the developing world / QJM 93:715~731
Christ A / 2006 / Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients / Intensive Care Med 32:1423~1427
Isbister GK / 2004 / Aspiration pneumonitis in an overdose population:frequency, predictors, and outcomes / Crit Care Med 32:88~93
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