지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To investigate the possibility of development as a whitening agent using pomegranate (Punica granatum L., Punicaceae)leaf extracts, we measured 1-diphenyl-2-picryl hydroazyl (DPPH) assay, nitroblue tetrazolium/xanthine oxidase (NBT/XO)assay, intracellular reactive oxygen species (ROS) scavenging assay, tyrosinase assay and melittin-induced intracellular Ca2+ mobilization and β-hexosaminidase release in B16 melanoma cells. Pomegranate leaf extracts had dose-dependently anti-oxidant activity in DPPH, NBT/XO and intracellular ROS assay. Pomegranate leaf extracts significantly inhibited purified tyrosinase activity using both substrates, L-3,4-dihydroxy-L-phenylalanine (L-DOPA) and L-tyrosine. On the other hand, pomegranate leaf extracts significantly inhibited melittin-induced intracellular Ca2+ mobilization and β-hexosaminidase release in B16 melanoma cells. Therefore, these results suggest that pomegranate leaf extracts may be useful for the development as whitening agents.
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참고문헌 (19)
참고문헌 신청
Balwani S / 2011 / 2-Methyl-pyran-4-one-3-O-beta-D-glucopyranoside isolated from leaves of Punicagranatum inhibits the TNFalpha-induced cell adhesion moleculesexpression by b
Banerjee N / 2012 / Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflamm
Cho YJ / 1999 / Silicainduced generation of reactive oxygen species in Rat2 fibroblast: role in activation of mitogen-activated protein kinase / Biochem Biophys Res Commun 26
Das S / 2012 / Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino
Diwakar G / 2012 / Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts / Fitoterapia 83 : 989 ~ 995
Banerjee N / 2012 / Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflamm
Cho YJ / 1999 / Silicainduced generation of reactive oxygen species in Rat2 fibroblast: role in activation of mitogen-activated protein kinase / Biochem Biophys Res Commun 26
Das S / 2012 / Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino
Diwakar G / 2012 / Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts / Fitoterapia 83 : 989 ~ 995
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