지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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For the purpose of searching for whitening resources using essential oil of herb, the antioxidative activity and melanogenesis of Geranium (Palargonium graveolens) oil were examined in cultured human skin melanoma cells (SK-MEL-3).
the cell viability, superoxide dismutase (SOD)-like activity, inhibitory activity of lipid peroxidation, tyrosinase activity and total amount of melanin were measured by colorimetric assay. For this experiment, SK-MEL-3 cells were treated with the media containing 25~55 μU/mL, glucose oxidase (GO) for 4 hours, and assessed for the cytotoxicity. GO significantly decreased cell viability compared with control and XTT_50 value was determined at 45 μU/mL of GO. In the antioxidative activity of Geranium oil, it showed SOD-like activity and the inhibitory activity of lipid peroxidation. While, in the melanogenesis of Geranium oil, Geranium oil significantly decreased the tyrosinase activity and total amount of melanin which were increased by GO-induced cytotoxicity. From these results, it is suggested that Geranium oil was effective in the protection of GO-induced cytotoxicity by antioxidative activity and inhibitory effect of melanogenesis. Finally, an essential oil such as Geranium oil may be a putative agent for the improvement of whitening effect.
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참고문헌 (35)
참고문헌 신청
Park ST / 1996 / Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by anti-oxidants and NMDA receptor antagonists / Neurotoxicol 17:37~49
Parviz O / 2007 / Antistreptococcal and Antioxidant Activity of Essential Oil from Matricarea chamomile L / Biol Sci 2(2):155~160
Rosen D / 1993 / Mutation in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis / Nature (London) 362:59~62
Sankar D / 2006 / Effect of Sesame Oil on Diuretics or β-blocker in the modulation of Blood Pessure, Anthropometry, Lipid Profile, and Redox status / Yale J Biol Med 79(1):19~26
Tiziana BM / 1998 / Antimicrobial and antioxidant properties of some comercial essential oils / Rlavour Fragr J 13:235~244
Parviz O / 2007 / Antistreptococcal and Antioxidant Activity of Essential Oil from Matricarea chamomile L / Biol Sci 2(2):155~160
Rosen D / 1993 / Mutation in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis / Nature (London) 362:59~62
Sankar D / 2006 / Effect of Sesame Oil on Diuretics or β-blocker in the modulation of Blood Pessure, Anthropometry, Lipid Profile, and Redox status / Yale J Biol Med 79(1):19~26
Tiziana BM / 1998 / Antimicrobial and antioxidant properties of some comercial essential oils / Rlavour Fragr J 13:235~244
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