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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 202 - 207 (6page)
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Background/Aims: CpG island methylator phenotype (CIMP)- high colorectal cancers (CRCs) have distinct clinicopathological features from their CIMP-low/negative CRC counterparts. However, controversy exists regarding the prognosis of CRC according to the CIMP status. Therefore, this study examined the prognosis of Korean patients with colon cancer according to the CIMP status. Methods: Among a previous cohort population with CRC, a total of 154 patients with colon cancer who had available tissue for DNA extraction were included in the study. CIMP-high was defined as ≥3/5 methylated markers using the five-marker panel (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1). Results: CIMP-high and CIMP-low/negative cancers were observed in 27 patients (17.5%) and 127 patients (82.5%), respectively. Multivariate analysis adjusting for age, gender, tumor location, tumor stage and CIMP and microsatellite instability (MSI) statuses indicated that CIMP-high colon cancers were associated with a significant increase in colon cancer-specific mortality (hazard ratio [HR], 3.23; 95% confidence interval [CI], 1.20 to 8.69; p=0.02). In microsatellite stable cancers, CIMP-high cancer had a poor survival outcome compared to CIMP-low/negative cancer (HR, 2.91; 95% CI, 1.02 to 8.27; p=0.04). Conclusions: Regardless of the MSI status, CIMP-high cancers had poor survival outcomes in Korean patients.
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참고문헌 (25)
참고문헌 신청
Boland CR / 1998 / A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria
Dahlin AM / 2010 / The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status / Clin Cancer Res 16
Greene FL / 2002 / AJCC cancer staging manual / Springer-Verlag
Hawkins N / 2002 / CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability / Gastroenterology 122 : 1376 ~ 1387
Hoang JM / 1997 / BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines / Cancer Res 57 : 300 ~ 303
Dahlin AM / 2010 / The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status / Clin Cancer Res 16
Greene FL / 2002 / AJCC cancer staging manual / Springer-Verlag
Hawkins N / 2002 / CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability / Gastroenterology 122 : 1376 ~ 1387
Hoang JM / 1997 / BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines / Cancer Res 57 : 300 ~ 303
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