지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 67 - 72 (6page)
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Background/Aims: We aimed to evaluate the clinical characteristics and prognosis of Crohn’s disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. Methods: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement. Results: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677). Conclusions: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes.
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참고문헌 (20)
참고문헌 신청
Freeman HJ / 2014 / Natural history and long-term clinical course of Crohn's disease / World J Gastroenterol 20:31~36
Keh C / 2005 / Jejunal Crohn's disease is associated with a higher postoperative recurrence rate than ileocaecal Crohn's disease / Colorectal Dis 7:366~368
Lazarev M / 2013 / Relationship between proximal Crohn's disease location and disease behavior and surgery: a cross-sectional study of the IBD Genetics Consortium / Am J Gastroenterol 108:106~112
Peyrin-Biroulet L / 2010 / The natural history of adult Crohn's disease in population-based cohorts / Am J Gastroenterol 105:289~297
Jess T / 2007 / Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark / Inflamm Bowel Dis 13:481~489
Keh C / 2005 / Jejunal Crohn's disease is associated with a higher postoperative recurrence rate than ileocaecal Crohn's disease / Colorectal Dis 7:366~368
Lazarev M / 2013 / Relationship between proximal Crohn's disease location and disease behavior and surgery: a cross-sectional study of the IBD Genetics Consortium / Am J Gastroenterol 108:106~112
Peyrin-Biroulet L / 2010 / The natural history of adult Crohn's disease in population-based cohorts / Am J Gastroenterol 105:289~297
Jess T / 2007 / Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark / Inflamm Bowel Dis 13:481~489
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