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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 420 - 425 (6page)
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Background/Aims: Although mucosal healing (MH) has been considered a treatment goal for patients with ulcerative colitis (UC), the risk factors predictive of relapse in patients who achieve MH are unknown. Because the platelet count has been shown to be a marker of inflammation in inflammatory bowel diseases, this study aimed to assess whether the platelet count could predict relapse in UC patients with MH. Methods: A prospective observational study was performed. UC patients with MH were consecutively enrolled in the study and monitored for at least 2 years or until relapse. The correlation between the incidence of relapse and the platelet count at the time of study enrollment was examined. Results: In total, 43 patients were enrolled, and 14 patients (33%) relapsed. The median platelet count at the time of enrollment in the patients who relapsed significantly differed from that in the patients who did not relapse (27.2×104/μL vs 23.8×104/μL, respectively; p=0.016). A platelet count >25.0×104/μL was a significant risk factor for relapse based on a multivariate analysis (hazard ratio, 4.85; 95% confidence interval, 1.07 to 25.28), and according to the Kaplan-Meier analysis, this cutoff could identify patients susceptible to relapse (p=0.041, log-rank test). Conclusions: The platelet count could be used as a predictor of relapse in UC patients with MH.
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참고문헌 (26)
참고문헌 신청
Peyrin-Biroulet L / 2011 / Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease / J Crohns Colitis 5:477~483
Lobaton T / 2013 / A new rapid quantitative test for fecal calprotectin predicts endoscopic activity in ulcerative colitis / Inflamm Bowel Dis 19:1034~1042
Onal IK / 2012 / The value of fecal calprotectin as a marker of intestinal inflammation in patients with ulcerative colitis / Turk J Gastroenterol 23:509~514
Nakarai A / 2013 / Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test / Am J Gastroenterol 108:83~89
Takashima S / 2015 / Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test / Am J Gastroenterol 110:873~880
Lobaton T / 2013 / A new rapid quantitative test for fecal calprotectin predicts endoscopic activity in ulcerative colitis / Inflamm Bowel Dis 19:1034~1042
Onal IK / 2012 / The value of fecal calprotectin as a marker of intestinal inflammation in patients with ulcerative colitis / Turk J Gastroenterol 23:509~514
Nakarai A / 2013 / Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test / Am J Gastroenterol 108:83~89
Takashima S / 2015 / Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test / Am J Gastroenterol 110:873~880
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