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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 18 - 27 (10page)
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초록· 키워드
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Conventional medical treatment for ulcerative colitis canhave limited efficacy or severe adverse reactions requiringadditional treatment or colectomy. Hence, different biologicalagents that target specific immunological pathways are beinginvestigated for treating ulcerative colitis. Anti-tumor necrosisfactor (TNF) agents were the first biologics to be usedfor treating inflammatory bowel disease. For example, infliximaband adalimumab, which are anti-TNF agents, are beingused for treating ulcerative colitis. Recently, golimumab,another anti-TNF agent, and vedolizumab, an anti-adhesiontherapy, have been approved for ulcerative colitis by the U.S.
Food and Drug Administration. In addition, new medicationssuch as tofacitinib, a Janus kinase inhibitor, and etrolizumab,another anti-adhesion therapy, are emerging as therapeuticagents. Therefore, there is a need for further studies toselect appropriate patient groups for these biologics and toimprove the outcomes of ulcerative colitis treatment throughappropriate medical usage.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Afif W / 2010 / Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease / Am J Gastroenterol 105
Aratari A / 2008 / Colectomy rate in acute severe ulcerative colitis in the infliximab era / Dig Liver Dis 40 : 821 ~ 826
Bendtzen K / 2009 / I
Colombel JF / 2010 / Infliximab, azathioprine, or combination therapy for Crohn’s disease / N Engl J Med 362 : 1383 ~ 1395
Feagan BG / 2013 / Vedolizumab as induction and maintenance therapy for ulcerative colitis / N Engl J Med 369 : 699 ~ 710
Aratari A / 2008 / Colectomy rate in acute severe ulcerative colitis in the infliximab era / Dig Liver Dis 40 : 821 ~ 826
Bendtzen K / 2009 / I
Colombel JF / 2010 / Infliximab, azathioprine, or combination therapy for Crohn’s disease / N Engl J Med 362 : 1383 ~ 1395
Feagan BG / 2013 / Vedolizumab as induction and maintenance therapy for ulcerative colitis / N Engl J Med 369 : 699 ~ 710
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