지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 220 - 227 (8page)
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초록· 키워드
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Background/Aims: Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms.
Methods: Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers. Results: In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSIL], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included.
Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987). Conclusions: The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.
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참고문헌 (30)
참고문헌 신청
Boland CR / 1998 / A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer / Cancer Res 58:5248~5257
Shah SN / 2010 / Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes / Cancer Res 70:431~435
Boland CR / 2010 / Microsatellite instability in colorectal cancer / Gastroenterology 138(e3):2073~2087
Liu P / 2005 / Microsatellite instability in gastric cancer and pre-cancerous lesions / World J Gastroenterol 11:4904~4907
Seo HM / 2009 / Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype / J Surg Oncol 99:143~147
Shah SN / 2010 / Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes / Cancer Res 70:431~435
Boland CR / 2010 / Microsatellite instability in colorectal cancer / Gastroenterology 138(e3):2073~2087
Liu P / 2005 / Microsatellite instability in gastric cancer and pre-cancerous lesions / World J Gastroenterol 11:4904~4907
Seo HM / 2009 / Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype / J Surg Oncol 99:143~147
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