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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 378 - 383 (6page)
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초록· 키워드
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Background/Aims: This study evaluated the relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) by comparing the incidence rates of NAFLD in relation to serum uric acid levels in apparently healthy subjects during a 5-year period.
Methods: Among 15,638 healthy Korean subjects who participated in a health-screening program in 2003 and 2008, respectively, 4954 subjects without other risk factors were enrolled in this study. We compared the incidence rates of NAFLD in 2008 with respect to baseline uric acid levels. Results: In 2003,serum uric acid levels were categorized into the following quartiles: 0.6-3.9, 3.9-4.8, 4.8-5.9, and 5.9-12.6mg/dL. The incidence of NAFLD in 2008 increased with the level of baseline uric acid (5.6%, 9.8%,16.2%, and 20.9%, respectively; p＜0.05). Multiple logistic regression analysis demonstrated that hyperuricemia was associated with the development of NAFLD. When compared to the subjects in quartile 1,the odds ratio (OR) for the incidence of NAFLD for quartiles 2, 3, and 4 were 1.53 (95% confidence interval [CI], 1.09-2.16; p=0.014], 1.69 (95% CI, 1.17-2.44;p=0.005), and 1.84 (95% CI, 1.25-2.71; p=0.002),respectively. Conclusions: High serum uric acid levels appear to be associated with an increased risk of the development of NAFLD.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abuja PM / 1999 / Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein / FEBS Lett 446 : 305 ~ 308
Adams LA / 2005 / Recent concepts in non-alcoholic fatty liver disease / Diabet Med 22 : 1129 ~ 1133
Chitturi S / 2002 / NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome / Hepatology 35 : 373 ~ 379
Cigolini M / 1995 / Hyperuricaemia: relationships to body fat distribution and other components of the insulin resistance syndrome in 38-year-old healthy men and women / Int
Conen D / 2004 / Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country / BMC Public Health 4 : 9 ~
Adams LA / 2005 / Recent concepts in non-alcoholic fatty liver disease / Diabet Med 22 : 1129 ~ 1133
Chitturi S / 2002 / NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome / Hepatology 35 : 373 ~ 379
Cigolini M / 1995 / Hyperuricaemia: relationships to body fat distribution and other components of the insulin resistance syndrome in 38-year-old healthy men and women / Int
Conen D / 2004 / Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country / BMC Public Health 4 : 9 ~
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