지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 298 - 305 (8page)
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초록· 키워드
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Background/Aims: We aimed to evaluate survival time and prognostic factors in patients with advanced unresectable cholangiocarcinoma who have not received surgery, chemotherapy, or radiotherapy. Methods: A total of 1,377 patients, who were diagnosed with primary cholangiocarcinoma between 1996 and 2002, were reviewed retrospectively according to the following inclusion criteria: histologically proven primary adenocarcinoma arising from the bile-duct epithelium, advanced unresectable stages, no severe comorbidity that can affect survival time, and no history of surgery, chemotherapy, or radiotherapy. Results: Of the 1,377 cases reviewed, 330 patients complied with the inclusion criteria and were thus eligible to participate in this study; 203 had intrahepatic cholangiocarcinoma and 127 had hilar cholangiocarcinoma.
The overall survival time of the entire cohort (n=330) was median 3.9 months (range; 0.2 to 67.1). The survival time was significantly shorter in the intrahepatic cholangiocarcinoma group (3.0±5.3 months) than in the hilar cholangiocarcinoma group (5.9±10.1 months; Kaplan-Meier survival analysis). Multivariate analysis revealed that distant metastasis was a poor prognostic factor for intrahepatic cholangiocarcinoma (p＜ 0.001), baseline serum albumin ＞3.0 g/dL was a favorable prognostic factor (p=0.02), and baseline serum carcinoembryonic antigen level ＞30 ng/mL was a poor prognostic factor for hilar cholangiocarcinoma (p=0.01). Conclusions: The median survival of advanced unresectable cholangiocarcinoma is dismal.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bismuth H / 1988 / Resection or palliation: priority of surgery in the treatment of hilar cancer / World J Surg 12 : 39 ~ 47
Burke EC / 1998 / Hilar cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system / Ann S
Connor S / 2007 / Palliation for suspected unresectable hilar cholangiocarcinoma / Eur J Surg Oncol 33 : 341 ~ 345
D'Angelica MI / 2004 / Resectable hilar cholangiocarcinoma: surgical treatment and long-term outcome / Surg Today 34 : 885 ~ 890
Isaji S / 1999 / Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan / J Hepatobiliary Pancreat Surg 6 : 108 ~ 116
Burke EC / 1998 / Hilar cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system / Ann S
Connor S / 2007 / Palliation for suspected unresectable hilar cholangiocarcinoma / Eur J Surg Oncol 33 : 341 ~ 345
D'Angelica MI / 2004 / Resectable hilar cholangiocarcinoma: surgical treatment and long-term outcome / Surg Today 34 : 885 ~ 890
Isaji S / 1999 / Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan / J Hepatobiliary Pancreat Surg 6 : 108 ~ 116
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