지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 363 - 370 (8page)
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Background/Aims: To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). Methods: A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC score changes on treatment day 3. Laboratory data and DIC scores were assessed prospectively at 2-day intervals. Results: DIC reversal rates >75%were attained on day 7. In the DIC reversal group, statistically significant differences from baseline were observed in interleukin-6 and C-reactive protein levels within 5 days. Patients with no DIC score improvements after treatment with AT alone experienced slow improvement on a subsequent combination therapy with rTM. Although a subgroup with biliary drainage showed greater improvement in DIC scores than did the nondrainage subgroup, the mean DIC score showed improvement even in the nondrainage subgroup alone. Gastric cancer bleeding that was treated conservatively occurred in one patient. As for day 28 outcomes, three patients died from concurrent malignancies. Conclusions: Although this algorithm was found to be useful and safe for DIC patients with cholangitis, it may be better to administer rTM and AT simultaneously from day 1 if the plasma AT III level is less than 70%.
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참고문헌 (15)
참고문헌 신청
Abeyama K / 2005 / The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism / J Clin Invest 115 : 1267 ~ 1274
Aikawa N / 2011 / Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial / Sho
Bernard GR / 2001 / Efficacy and safety of recombinant human activated protein C for severe sepsis / N Engl J Med 344 : 699 ~ 709
Eguchi Y / 2010 / Efficacy of recombinant thrombomodulin in antithrombin substitution-resistant septic disseminated intravascular coagulation: results of a pilot study / J J
Esmon NL / 1982 / Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C / J Biol Chem 257 : 859 ~ 864
Aikawa N / 2011 / Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial / Sho
Bernard GR / 2001 / Efficacy and safety of recombinant human activated protein C for severe sepsis / N Engl J Med 344 : 699 ~ 709
Eguchi Y / 2010 / Efficacy of recombinant thrombomodulin in antithrombin substitution-resistant septic disseminated intravascular coagulation: results of a pilot study / J J
Esmon NL / 1982 / Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C / J Biol Chem 257 : 859 ~ 864
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