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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 590 - 603 (14page)
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초록· 키워드
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Nucleos(t)ide analogues (NUCs) and interferon have been used for several decades to treat chronic hepatitis B; however, the therapeutic response remains unsatisfactory. Although NUC therapy exhibits potent on-treatment viral suppression, frequent off-therapy virological relapses suggest an indefinite treatment course. Interferon modulates the innate and adaptive antiviral immune responses and thus increases the chance of viral eradication. Interferon therapy has the advantage of a finite duration, absence of drug resistance, and durable posttreatment responses. Therefore, the combination of NUCs and interferon can theoretically facilitate a synergistic therapeutic effect. This paper summarizes the current strategies of various combination therapies into three categories: the simultaneous “dual” strategy, sequential combination “add-on” strategy, and “switch” strategy. Generally, dual therapy exhibits greater on-treatment and off-therapy viral suppression and lower drug resistance compared with NUC monotherapy. Compared with interferon monotherapy, dual therapy has greater on-treatment viral suppression but shows no difference in off-therapy sustained virological responses. Specific add-on or switch strategies provide promising on-treatment efficacy in select patients. Pretreatment or on-treatment quantitative hepatitis B surface antigen and e antigen are predictive for the treatment efficacy of combination therapy. The optimal schedule of combination regimens and individualized therapy remain to be comprehensively evaluated.
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참고문헌 (22)
참고문헌 신청
Barbaro G / 2001 / Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B: an Italia
Belloni L / 2012 / IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA min
Boni C / 2007 / Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection / J Virol 81 : 4215 ~ 4225
Das A / 2008 / Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection / J Exp Med 205 : 2111 ~ 2124
European Association for the Study of the Liver / 2012 / EASL clinical practice guidelines: management of chronic hepatitis B virus infection / J Hepatol 57 : 167 ~ 185
Belloni L / 2012 / IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA min
Boni C / 2007 / Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection / J Virol 81 : 4215 ~ 4225
Das A / 2008 / Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection / J Exp Med 205 : 2111 ~ 2124
European Association for the Study of the Liver / 2012 / EASL clinical practice guidelines: management of chronic hepatitis B virus infection / J Hepatol 57 : 167 ~ 185
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