지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The importance of intracranial atherosclerotic disease (ICAD) as a cause of stroke is underscored as compared to that of extracranial carotid stenosis and nonvalvular atrial fibrillation. Recent large clinical trials of ICAD, which evaluated the effectiveness of anticoagulation and stenting to prevent thromboembolism and restore hemodynamic compromise, failed to reduce major vascular events in patients with ICAD. These trials showed the importance of optimal control of risk factors to reduce major vascular events in these patients. Recent advances in risk factors for ICAD are summarized, together with possible reasons for race-ethnic differences in the prevalence of ICAD. In addition, the failure of the major clinical trials of ICAD may be caused by limitations in the understanding of ICAD. Unlike in patients with extracranial carotid stenosis or atrial fibrillation, stroke associated with ICAD occurs in association with various stroke mechanisms such as in situ thrombotic occlusion, artery-to-artery embolism, hemodynamic insufficiency, and branch occlusion. In clinical trials of ICAD, patients with all these types of ICAD were included. However, treatment effects may differ among the different types of ICAD. Treatment strategies might be selected based on clinical features (including the time after onset) and serologic and neuroimaging biomarkers (including diffusion-weighted image pattern and plaque images). Additional clinical trials considering these features are needed.
목차
등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Liu W. / 2012 / Distribution of Moyamoya disease susceptibility polymorphism p. R4810K in RNF213 in East and Southeast Asian populations / Neurol Med Chir 52:299~303
Sang Hyuk Yim / 2012 / Prevalence and Epidemiological Features of Moyamoya Disease in Korea / Journal of Cerebrovascular and Endovascular Neurosurgery 14(2):75~78
Mazighi M. / 2006 / Prospective study of symptomatic atherothrombotic intracranial stenoses : the GESICA study / Neurology 66:1187~1191
Kasner SE. / 2006 / Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis / Circulation 113:555~563
Arenillas JF. / 2001 / Progression and clinical recurrence of symptomatic middle cerebral artery stenosis : a longterm follow-up transcranial Doppler ultrasound study / Stroke 32:2898~2904
Sang Hyuk Yim / 2012 / Prevalence and Epidemiological Features of Moyamoya Disease in Korea / Journal of Cerebrovascular and Endovascular Neurosurgery 14(2):75~78
Mazighi M. / 2006 / Prospective study of symptomatic atherothrombotic intracranial stenoses : the GESICA study / Neurology 66:1187~1191
Kasner SE. / 2006 / Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis / Circulation 113:555~563
Arenillas JF. / 2001 / Progression and clinical recurrence of symptomatic middle cerebral artery stenosis : a longterm follow-up transcranial Doppler ultrasound study / Stroke 32:2898~2904
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