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자료유형
학술저널
저자정보
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중학회지 제7권 제2호
발행연도
2005.1
수록면
197 - 207 (11page)

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Background and objectives: Compared with brain activation of normal controls, the brain activation patterns of patients with Broca’s or anomic aphasia were investigated by fMRI study with 2 speech production tasks. Methods: Nine patients with Broca’s aphasia and 8 subjects of anomic aphasia were participated in this study. In normal control group, we studied 9 healthy adults using 2 tasks. All subjects were right handed. Functional image was performed during 2 tasks of block design (4 activation blocks, 5 control blocks per session); (1) picture naming, (2) word reading. All data processing and statistical analysis were performed using SPM 99 and statistical significance level was set at p<0.01. Results: In picture naming task, the fusiform gyrus, superior temporal and middle temporal gyrus, superior frontal gyrus, middle frontal gyrus, prefrontal gyrus of the left hemisphere were predominantly activated. During word reading tasks, activations of the left middle temporal and left angular gyri were remarkable, and the areas of the right inferior parietal lobule and right fusiform gyrus were activated. During picture naming and word reading tasks, the strong activation of contralateral Broca’s area was typical in Broca’s aphasic patients, but in anomic aphasic patients, the strong activation of ipsilateral perilesional Broca’s area was produced. Conclusion: There are evidences of brain plasticity of an expressive language area into the right Broca’ s homologue area. The right hemisphere and undamaged perilesional areas in the left hemisphere play a role in some patients, especially due to severity. (Korean Journal of Stroke 2005;7(2): 197~207)

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