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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and distribution of cerebral thromboemboli. Currently, magnetic resonance (MR) or computed tomography (CT) angiography visualizes the obstruction of blood flow within the vessel lumen rather than the thrombus itself. The present visualization method, which relies on observation of the dense artery sign (the appearance of cerebral thrombi on a non-enhanced CT), suffers from low sensitivity. When translated into the clinical setting, direct thrombus imaging is likely to enable individualized acute stroke therapy by allowing clinicians to detect the thrombus with high sensitivity, assess the size and nature of the thrombus more precisely, serially monitor the therapeutic effects of thrombolysis, and detect post-treatment recurrence. This review is intended to provide recent updates on stroke-related direct thrombus imaging using MR imaging, positron emission tomography, or CT
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등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
Mozaffarian D / 2016 / Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association / Circulation 133:e38~e360
Kirmani JF / 2012 / Advances in thrombolytics for treatment of acute ischemic stroke / Neurology 79:S119~S125
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group / 1995 / Tissue plasminogen activator for acute ischemic stroke / N Engl J Med 333:1581~1587
Adibhatla RM / 2008 / Tissue plasminogen activator(tPA)and matrix metalloproteinases in the pathogenesis of stroke : therapeutic strategies / CNS Neurol Disord Drug Targets 7:243~253
Gravanis I / 2008 / Tissue-type plasminogen activator as a therapeutic target in stroke / Expert Opin Ther Targets 12:159~170
Kirmani JF / 2012 / Advances in thrombolytics for treatment of acute ischemic stroke / Neurology 79:S119~S125
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group / 1995 / Tissue plasminogen activator for acute ischemic stroke / N Engl J Med 333:1581~1587
Adibhatla RM / 2008 / Tissue plasminogen activator(tPA)and matrix metalloproteinases in the pathogenesis of stroke : therapeutic strategies / CNS Neurol Disord Drug Targets 7:243~253
Gravanis I / 2008 / Tissue-type plasminogen activator as a therapeutic target in stroke / Expert Opin Ther Targets 12:159~170
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