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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제1호
- 발행연도
- 2015.1
- 수록면
- 53 - 58 (6page)
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Purpose: Endocrine-disrupting chemicals interfere with the endocrine system and therefore affect growth and pubertal progression. The study aim was to compare the growth and pubertal progression in wild-type female rats with different bedding types.
Methods: Twenty 5-week-old female wild-type Sprague Dawley rats were randomly assigned to two groups with different bedding types: one group received wood shaving bedding, while a second group received corncob bedding. We determined crown-rump length and body weight as anthropometric measurements and assessed the serum growth hormone (GH) and estradiol levels. The gh1 mRNA expression levels were compared using quantitative real time transcription polymerase chain reaction. The estrous cycle was evaluated by vaginal smear.
Results: The anthropometric measurements were not significantly different between the two groups. The mean relative expression of the gh1 gene was lower in the corncob bedding group than that in the wood shaving group (P=0.768).
Meanwhile serum GH and estradiol were increased in the wood shaving bedding group; however this difference was not statistically significant. The time to first estrus and the length of the estrous cycle were increased in the corncob bedding group; the proportion of normal estrous cycles was also decreased. These findings indicate irregularities in the estrous cycle.
Conclusion: Endocrine-disrupting chemicals in corncob bedding might be associated with time to first estrus and length of the estrous cycle. Therefore, the type of bedding should be considered as a factor affecting pubertal progression in rodents.
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참고문헌 (21)
참고문헌 신청
Adlercreutz H / 1997 / Phyto-oestrogens and Western diseases / Ann Med 29 : 95 ~ 120
Borjesson AE / 2010 / The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth / J Bone Miner Res 25 : 2690 ~ 2700
Diamanti-Kandarakis E / 2009 / Endocrine-disrupting chemicals: an Endocrine Society scientific statement / Endocr Rev 30 : 293 ~ 342
Freeman ME. / 1994 / The physiology of reproduction / Raven Press : 613 ~ 658
Goldman JM / 2007 / The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies / Birth Defects Res B Dev Reprod Toxicol 80 : 84
Borjesson AE / 2010 / The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth / J Bone Miner Res 25 : 2690 ~ 2700
Diamanti-Kandarakis E / 2009 / Endocrine-disrupting chemicals: an Endocrine Society scientific statement / Endocr Rev 30 : 293 ~ 342
Freeman ME. / 1994 / The physiology of reproduction / Raven Press : 613 ~ 658
Goldman JM / 2007 / The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies / Birth Defects Res B Dev Reprod Toxicol 80 : 84
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