지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제23권 제2호
- 발행연도
- 2018.1
- 수록면
- 88 - 93 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Methods: The medical records of 66 patients (42 males) treated for medulloblastoma (n=56) or PNET (n=10) in childhood between January 2000 and December 2014 at Seoul National University Children’s Hospital were retrospectively reviewed. A total of 21 patients (18 high-risk medulloblastoma and 3 PNET) underwent high-dose chemotherapy and autologous stem cell rescue (HDCT/ASCR) Results: During the median 7.6 years of follow-up, 49 patients (74%) developed transient (n=12) or permanent (n=37) hypothyroidism at a median 3.8 years of follow-up (2.9–4.6 years). Younger age (<5 years) at radiation exposure (P=0.014 vs. ≥9 years) and HDCT (P=0.042) were significantly predictive for hypothyroidism based on log-rank test. However, sex, type of tumor, and dose of craniospinal irradiation (less vs. more than 23.4 Gy) were not significant predictors. Cox proportional hazard model showed that both younger age (<5 years) at radiation exposure (hazard ratio [HR], 3.1; vs. ≥9 years; P=0.004) and HDCT (HR, 2.4; P=0.010) were significant predictors of hypothyroidism. Conclusion: Three-quarters of patients with pediatric medulloblastoma or PNET showed thyroid dysfunction, and over half had permanent thyroid dysfunction. Thus, frequent monitoring of thyroid function is mandatory in all patients treated for medulloblastoma or PNET, especially, in very young patients and/or high-risk patients recommended for HDCT/ASCR.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ostrom QT / 2016 / CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013 / Neuro Oncol 18(suppl_5):v1~v75
Massimino M / 2016 / Childhood medulloblastoma / Crit Rev Oncol Hematol 105:35~51
Packer RJ / 2006 / Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma / J Clin Oncol 24:4202~4208
Jereczek-Fossa BA / 2004 / Radiotherapy-induced thyroid disorders / Cancer Treat Rev 30:369~384
Constine LS / 1984 / Thyroid dysfunction after radiotherapy in children with Hodgkin's disease / Cancer 53:878~883
Massimino M / 2016 / Childhood medulloblastoma / Crit Rev Oncol Hematol 105:35~51
Packer RJ / 2006 / Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma / J Clin Oncol 24:4202~4208
Jereczek-Fossa BA / 2004 / Radiotherapy-induced thyroid disorders / Cancer Treat Rev 30:369~384
Constine LS / 1984 / Thyroid dysfunction after radiotherapy in children with Hodgkin's disease / Cancer 53:878~883
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical course of infants with congenital heart disease who developed thyroid dysfunction within 100 days
Annals of Pediatirc Endocrinology & Metabolism
2017 .01
-
Medulloblastoma in the Molecular Era
대한신경외과학회지
2018 .01
-
Update on the Management of Thyroid Disease during Pregnancy
Endocrinology and Metabolism
2016 .01
-
Thyroid dysfunction and subfertility
Clinical and experimental reproductive medicine : CERM
2015 .01
-
Isolated Supratentorial Intraventricular Recurrence of Medulloblastoma
대한신경외과학회지
2015 .01
-
Thyroid : Cons
대한임상종양학회 학술대회지
2015 .02
-
Tandem High-dose Chemotherapy without Craniospinal Irradiation in Treatment of Non-metastatic Malignant Brain Tumors in Very Young Children
Journal of Korean Medical Science
2020 .01
-
Thyroid dysfunction in very low birth weight preterm infants
Clinical and Experimental Pediatrics
2015 .01
-
Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-based Cohort Study
Endocrinology and Metabolism
2018 .01
-
Diagnosis and Management of Thyroid Disease during Pregnancy and Postpartum: 2023 Revised Korean Thyroid Association Guidelines
Endocrinology and Metabolism
2023 .06
-
선천성 갑상샘저하증의 진단과 치료
대한의사협회지
2023 .03
-
Neurocognitive Function and Health-Related Quality of Life in Pediatric Korean Survivors of Medulloblastoma
Journal of Korean Medical Science
2016 .01
-
임신과 갑상선질환
대한의사협회지
2018 .01
-
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
Endocrinology and Metabolism
2023 .04
-
Thyroid Nodule Requiring Thyroidectomy in a Patient with Thyroid Hemiagenesis
The Journal of Endocrine Surgery
2021 .12
-
Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for High-Grade Gliomas in Children and Adolescents
Journal of Korean Medical Science
2017 .01
-
Predictors Associated with the Maintenance of Normal Thyroid Function after Unilateral Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma
The Journal of Endocrine Surgery
2019 .01
-
Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study
Clinical and Molecular Hepatology
2015 .01
-
Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
Journal of Korean Medical Science
2015 .01
-
Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor
Cancer Research and Treatment
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0