Purpose: The purpose of the study was to investigate the correlation of nurses' professionalism and job satisfaction with the level of delegation of nursing activities in long-term care hospitals. Methods: Participants in this study were 154 nurses working in 13 long-term care hospitals in the J region. Data were collected between September 24 and October 26, 2012 using self-report surveys with structured questionnaires. Collected data were analyzed using SPSS 12.0 with the following statistics: descriptive statistics, Pearson correlation coefficients, t-test, ANOVA, multiple regression analysis and Cronbach's alpha. Results: The mean score for level of delegation of nursing activities in long-term care hospital was 1.25 points (SD=±0.57), for professionalism, 3.29 points (SD = ± 0.40) and for job satisfaction, 2.61 points (SD = ±0.33). Level of delegation of nursing activity showed a significant inverse correlation with professionalism and job satisfaction. Professionalism of nurses working in long-term care hospitals had a significant positive correlation with job satisfaction. Conclusion: Guidelines for legal and institutional policies, standards, methods and procedures for delegation of nursing activities in long-term care hospitals are needed and efforts to improve professionalism and job satisfaction are needed.