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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 635 - 640 (6page)
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이 논문의 연구 히스토리 (2)
2012
Alterations in hyperpolarization-activated cyclic nucleotide-gate cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus
Yun-Jung Oh
,
Jongju Na
,
Ji-Heon Jeong
외 6명
대한체질인류학회 학술대회 연제 초록
2012.05
학술대회자료
Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus
Yun-Jung Oh
,
Jongju Na
,
Ji-Heon Jeong
외 4명
BMB Reports
2012.01
학술저널
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To understand the effects of HCN as potential mediators in the pathogenesis of epilepsy that evoke long-term impaired excitability; the present study was designed to elucidate whether the alterations of HCN expression induced by status epilepticus (SE) is responsible for epileptogenesis. Although HCN1 immunoreactivity was observed in the hippocampus, its immunoreactivities were enhanced at 12 hrs following SE. Although, HCN1immunoreactivities were reduced in all the hippocampi at 2weeks, a re-increase in the expression at 2-3 months following SE was observed. In contrast to HCN1, HCN 4 expressions were un-changed, although HCN2 immunoreactive neurons exhibited some changes following SE. Taken together, our findings suggest that altered expressions of HCN1 following SE may be mainly involved in the imbalances of neurotransmissions to hippocampal circuits; thus, it is proposed that HCN1 may play an important role in the epileptogenic period as a compensatory response. [BMB Reports 2012; 45(11): 635-640]
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참고문헌 (22)
참고문헌 신청
Bender, R. A. / 2001 / Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles
Bender, R. A. / 2003 / Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of
Brewster, A. / 2002 / Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner / J
Chen, K. / 1999 / Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits / Nat. Med. 5 : 888 ~ 894
Chen, K. / 2001 / Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability / Nat. Med. 7 :
Bender, R. A. / 2003 / Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of
Brewster, A. / 2002 / Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner / J
Chen, K. / 1999 / Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits / Nat. Med. 5 : 888 ~ 894
Chen, K. / 2001 / Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability / Nat. Med. 7 :
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