지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 382 - 387 (6page)
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초록· 키워드
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Corn silk (CS) has long been consumed as a traditional herb inKorea. Maysin is a major flavonoid of CS. The effects ofmaysin on macrophage activation were evaluated, using themurine macrophage RAW 264.7 cells. Maysin was isolatedfrom CS by methanol extraction, and preparative C18 reversephase column chromatography. Maysin was nontoxic up to100 μg/ml, and dose-dependently increased TNF-α secretionand iNOS production by 11.2- and 4.2-fold, respectively,compared to untreated control. The activation and subsequentnuclear translocation of NF-κB was substantially enhancedupon treatment with maysin (1-100 μg/ml). Maysin alsostimulated the phosphorylation of Akt and MAPKs (ERK, JNK).
These results indicated that maysin activates macrophages tosecrete TNF-α and induce iNOS expression, via the activationof the Akt, NF-κB and MAPKs signaling pathways. Theseresults suggest for the first time that maysin can be a newimmunomodulator, enhancing the early innate immunity.
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참고문헌 (24)
참고문헌 신청
Bastien, J. W. / 1983 / Pharmacopeia of qollahuaya andeans / J. Ethnopharmacol 8 : 97 ~ 111
Bogdan, C. / 2001 / Nitric oxide and the immune response / Nat. Immunol 2 : 907 ~ 916
Caceres, A. / 1987 / Diuretic activity of plants used for the treatment of urinary ailments in Guatemala / J. Ethnopharmacol 19 : 233 ~ 245
Commins, S. P. / 2010 / Immunologic messenger molecules: Cytokines, interferons, and chemokines / J. Allergy Clin. Immunol 125 : 53 ~ 72
Feng, Y. H. / 2002 / Low dose of resveratrol enhanced immune response of mice / Acta Pharmacol. Sin 23 : 893 ~ 897
Bogdan, C. / 2001 / Nitric oxide and the immune response / Nat. Immunol 2 : 907 ~ 916
Caceres, A. / 1987 / Diuretic activity of plants used for the treatment of urinary ailments in Guatemala / J. Ethnopharmacol 19 : 233 ~ 245
Commins, S. P. / 2010 / Immunologic messenger molecules: Cytokines, interferons, and chemokines / J. Allergy Clin. Immunol 125 : 53 ~ 72
Feng, Y. H. / 2002 / Low dose of resveratrol enhanced immune response of mice / Acta Pharmacol. Sin 23 : 893 ~ 897
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