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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 609 - 617 (9page)
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초록· 키워드
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NAD(P)H:quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. When toxic quinones are reduced by NQO1, they are conjugated with glutathione or glucuronic acid and excreted from the cells. Based on this protective effect of NQO1, the use of dietary compounds to induce the expression of NQO1 has emerged as a promising strategy for cancer prevention. On the other hand, NQO1-mediated two-electron reduction converts certain quinone compounds (such as mitomycin C, E09, RH1 and -lapachone) to cytotoxic agents, leading to cell death. It has been known that NQO1 is expressed at high levels in numerous human cancers, including breast, colon, cervix, lung, and pancreas, as compared with normal tissues. This implies that tumors can be preferentially damaged relative to normal tissue by cytotoxic quinone drugs. Importantly, NQO1 has been shown to stabilize many proteins, including p53 and p33ING1b, by inhibiting their proteasomal degradation. This review will summarize the biological roles of NQO1 in cancer, with emphasis on recent findings and the potential of NQO1 as a therapeutic target for the cancer therapy.
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참고문헌 (23)
참고문헌 신청
Anwar A / 2002 / Interaction of the molecular chaperone Hsp70 with human NAD(P)H: quinone oxidoreductase 1 / J Biol Chem 277 : 14060 ~ 14067
Chang Gun Cho / 2006 / Association of the GSTP1 and NQO1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk / Journal of Korean Medical Science 21 (6) : 1075 ~ 107
Chen H / 1999 / Association of the NAD(P)H:quinone oxidoreducatase 609C?T polymorphism with a decreased lung cancer risk / Cancer Res 59 : 3045 ~ 3048
Cornblatt BS / 2007 / Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast / Carcinogenesis 28 : 1485 ~ 1490
Ernster L / 1958 / Soluble diaphorase in animal tissues / Acta Chem Scand 12 : 595 ~ 602
Chang Gun Cho / 2006 / Association of the GSTP1 and NQO1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk / Journal of Korean Medical Science 21 (6) : 1075 ~ 107
Chen H / 1999 / Association of the NAD(P)H:quinone oxidoreducatase 609C?T polymorphism with a decreased lung cancer risk / Cancer Res 59 : 3045 ~ 3048
Cornblatt BS / 2007 / Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast / Carcinogenesis 28 : 1485 ~ 1490
Ernster L / 1958 / Soluble diaphorase in animal tissues / Acta Chem Scand 12 : 595 ~ 602
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