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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 188 - 193 (6page)
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초록· 키워드
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Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte proliferation even under serum deficient condition. This effect of CaS was mediated by serotonin 2B receptor (5-HT2BR) related to the cell proliferation effect of 5-HT. We also confirmed that both CaS and 5-HT induced G1 progression via 5-HT2BR/ERK pathway in HaCaT cells. However, Akt pathway was additionally involved in upregulated expression levels of cyclin D1 and cyclin E induced by CaS by activating 5-HT2BR. Moreover, CaS and 5-HT induced cell migration in HaCaT cells via 5-HT2BR. However, 5-HT regulated cell migration only through ERK/AP-1/MMP9 pathway while additional Akt/NF-κB/MMP9 pathway was involved in the cell migration effect of CaS. These results suggest that CaS can enhance keratinocyte proliferation and migration. It might have potential as a reagent beneficial for wound closing and cell regeneration.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Kang K / 2010 / Induced synthesis of caffeoylserotonin in pepper fruits upon infection by the anthracnose fungus, Colletotrichum gloeosporioides / Sci Hortic 124:290~293
Choi J / 2010 / Cytoprotective activities of hydorxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells / Fitoterapia 81:1134~1141
Nguyen C / 2013 / Caffeoylserotonin protects human keratinocyte HaCaT Cells against $H_2O_2$ -induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 Pathway / Phytother Res 27:1810~1818
Munz B / 1997 / Novel type of glutathione peroxidase: expression and regulation during wound repair / Biochem J 326:579~585
O'Toole E / 1996 / Hydrogen peroxide inhibits human keratinocyte migration / Dermatol Surg 22:525~529
Choi J / 2010 / Cytoprotective activities of hydorxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells / Fitoterapia 81:1134~1141
Nguyen C / 2013 / Caffeoylserotonin protects human keratinocyte HaCaT Cells against
Munz B / 1997 / Novel type of glutathione peroxidase: expression and regulation during wound repair / Biochem J 326:579~585
O'Toole E / 1996 / Hydrogen peroxide inhibits human keratinocyte migration / Dermatol Surg 22:525~529
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