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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 400 - 405 (6page)
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Chronic stress induces neuronal cell death, which can cause nervous system disorders including Parkinson’s disease and Alzheimer’s disease. In this study, we evaluated the neuroprotective effects of Clematis terniflora extract (CTE) against corticosterone-induced apoptosis in rat pheochromocytoma (PC12) cells, and also investigated the underlying molecular mechanisms. At concentrations of 300 and 500 g/ml, CTE significantly decreased apoptotic cell death and mitochondrial damage induced by 200 M corticosterone. CTE decreased the expression levels of endoplasmic reticulum (ER) stress proteins GRP78, GADD153, and mitochondrial damage-related protein BAD, suggesting that it downregulates ER stress evoked by corticosterone. Furthermore, our results suggested that these protective effects were mediated by the upregulation of p-AKT and p-ERK1/2, which are involved in cell survival signaling. Collectively, our results indicate that CTE can lessen neural damage caused by chronic stress.
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참고문헌 (32)
참고문헌 신청
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Carlson LE / 2003 / Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients / Psychosom Med 65:571~581
McEwen BS / 1993 / Stress and the individual. Mechanisms leading to disease / Arch Intern Med 153:2093~2101
Mizoguchi K / 1992 / Stress induces neuronal death in the hippocampus of castrated rats / Neurosci Lett 138:157~160
Kendler KS / 1999 / Causal relationship between stressful life events and the onset of major depression / Am J Psychiatry 156:837~841
Carlson LE / 2003 / Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients / Psychosom Med 65:571~581
McEwen BS / 1993 / Stress and the individual. Mechanisms leading to disease / Arch Intern Med 153:2093~2101
Mizoguchi K / 1992 / Stress induces neuronal death in the hippocampus of castrated rats / Neurosci Lett 138:157~160
Kendler KS / 1999 / Causal relationship between stressful life events and the onset of major depression / Am J Psychiatry 156:837~841
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