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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 630 - 635 (6page)
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C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits a structure similar to the proangiogenic subgroup of the CXC chemokine family. Recently, accumulating evidence suggests that chemokines play a pivotal role in cancer progression and carcinogenesis. We examined the expression levels of 7 types of ELR＋ CXCLs messenger RNA (mRNA) in 264 clinical samples. We found that CXCL2 expression was stably down-regulated in 94% of hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues and some HCC cell lines. Moreover, CXCL2 overexpression profoundly attenuated HCC cell proliferation and growth and induced apoptosis in vitro. In animal studies, we found that overexpressing CXCL2 by lentivirus also apparently inhibited the size and weight of subcutaneous tumours in nude mice. Furthermore, we demonstrated that CXCL2 induced HCC cell apoptosis via both nuclear and mitochondrial apoptosis pathways. Our results indicate that CXCL2 negatively regulates the cell cycle in HCC cells via the ERK1/2 signalling pathway. These results provide new insights into HCC and may ultimately lead to the discovery of innovative therapeutic approaches of HCC.
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참고문헌 (32)
참고문헌 신청
Altekruse SF / 1975 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J Clin Oncol 27:1485~1491
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Yuen MF / 2009 / Hepatocellular carcinoma in the Asia pacific region / J Gastroenterol Hepatol 24:346~353
Toso C / 2011 / Liver transplantation for hepatocellular carcinoma: five steps to prevent recurrence / Am J Transplant 11:2031~2035
Bruix J / 2005 / Management of hepatocellular carcinoma / Hepatology 42:1208~1236
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Yuen MF / 2009 / Hepatocellular carcinoma in the Asia pacific region / J Gastroenterol Hepatol 24:346~353
Toso C / 2011 / Liver transplantation for hepatocellular carcinoma: five steps to prevent recurrence / Am J Transplant 11:2031~2035
Bruix J / 2005 / Management of hepatocellular carcinoma / Hepatology 42:1208~1236
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