지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 124 - 129 (6page)
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FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h. In addition, we demonstrated that topical application of PEP-1-FK506BP was transduced into mouse cornea and conjunctiva by immunohistochemistry. Furthermore, topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. These results suggest PEP-1-FK506BP as a potential therapeutic agent for dry eye diseases.
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참고문헌 (25)
참고문헌 신청
[학술지(
Ahn, E. H. / 2010 / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoyl phorbol-13-acetate-induced inflammation in mice / Toxicol 276 : 192 ~ 197
Behrens, A. / 2006 / Dysfunctional tear syndrome study group. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Dana, M. R. / 2002 / Role of immunity and inflammation in corneal and ocular surface diseases associated with dry eye / Ade. Exp. Med. Biol 506 : 729 ~ 738
De Paiva, C. S. / 2006 / Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry ey
Ahn, E. H. / 2010 / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoyl phorbol-13-acetate-induced inflammation in mice / Toxicol 276 : 192 ~ 197
Behrens, A. / 2006 / Dysfunctional tear syndrome study group. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Dana, M. R. / 2002 / Role of immunity and inflammation in corneal and ocular surface diseases associated with dry eye / Ade. Exp. Med. Biol 506 : 729 ~ 738
De Paiva, C. S. / 2006 / Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry ey
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