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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 153 - 158 (6page)
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초록· 키워드
오류제보하기
As FK506 binding proteins (FK506BPs) are known to play animportant role in the regulation of a variety of biological processesrelated to cell survival, this study was designed to examinedthe protective effects of FK506 binding protein 12(FK506BP) on low humidity air flow induced dry eye in a ratmodel using transduced PEP-1-FK506BP. After the topical applicationof PEP-1-FK506BP, tear volumes were markedly increasedand significant prevention of cornea damage was observedcompared with dry eye rats. Further, immunohistochemicalanalysis demonstrated that PEP-1-FK506BP markedlyprevented damage to the cornea, the bulbar conjunctiva, andthe palpebral conjunctiva epithelial lining compared with dryeye rats. In addition, caspase-3 and PARP expression levelswere found to be decreased. These results demonstrated thattopical application of PEP-1-FK506BP significantly amelioratesdry eye injury in an animal model. Thus, we suggest thatPEP-1-FK506BP can be developed as a new ophthalmic dropto treat dry eye diseases.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ahn EH / 2010 / Transduced PEP-1-ribosomal protein S3(rpS3)ameliorates 12-O-tetradecanoyl phorbol-13-acetate-induced inflammation in mice / Toxicol 276 : 192 ~ 197
Behrens A / 2006 / Dysfunctional tear syndrome study group. Dysfunctional tear syndrome:a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Chen W / 2008 / A murine model of dry eye induced by an intelligently controlled environmental system / Invest Ophthalmol Vis Sci 49 : 1386 ~ 1391
Chen W / 2009 / Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis / Exp Eye Res 89 : 311 ~ 318
Dietz GP / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr Pharm Biotechol 11 : 167 ~ 174
Behrens A / 2006 / Dysfunctional tear syndrome study group. Dysfunctional tear syndrome:a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Chen W / 2008 / A murine model of dry eye induced by an intelligently controlled environmental system / Invest Ophthalmol Vis Sci 49 : 1386 ~ 1391
Chen W / 2009 / Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis / Exp Eye Res 89 : 311 ~ 318
Dietz GP / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr Pharm Biotechol 11 : 167 ~ 174
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