지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 700 - 706 (7page)
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초록· 키워드
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Obesity is a worldwide epidemic as well as being a major risk factor for diabetes, cardiovascular diseases and several types of cancers. Obesity is mainly due to the overgrowth of adipose tissue arising from an imbalance between energy intake and energy expenditure. Adipose tissue, primarily composed of adipocytes, plays a key role in maintaining whole body energy homeostasis. In view of the treatment of obesity and obesity-related diseases, it is critical to understand the detailed signal transduction mechanisms of adipogenic differentiation.
Adipogenic differentiation is tightly regulated by many key signal cascades, including insulin signaling. These signal cascades generally transfer or amplify the signal by using serial tyrosine phosphorylations. Thus, protein tyrosine kinases and protein tyrosine phosphatases are closely related to adipogenic differentiation. Compared to protein tyrosine kinases, protein tyrosine phosphatases have received little attention in adipogenic differentiation. This review aims to highlight the involvement of protein tyrosine phosphatases in adipogenic differentiation and the possibility of protein tyrosine phosphatases as drugs to target obesity. [BMB Reports 2012;45(12): 700-706]
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참고문헌 (27)
참고문헌 신청
Cawthorn, W. P. / 2012 / Adipose tissue stem cells meet preadipocyte commitment:going back to the future / J. Lipid Res. 53 : 227 ~ 246
Choi, Hye-Ryung / 2012 / Protein Tyrosine Phosphatase Profiling Analysis of HIB-1B Cells during Brown Adipogenesis / Journal of Microbiology and Biotechnology 22 (7) : 1029
Cypess, A. M. / 2009 / Identification and importance of brown adipose tissue in adult humans / N. Engl. J. Med. 360 : 1509 ~ 1517
Farmer, S. R. / 2009 / Obesity: be cool, lose weight / Nature 458 : 839 ~ 840
Goldstein, B. J. / 1993 / Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation / Receptor 3 : 1 ~ 15
Choi, Hye-Ryung / 2012 / Protein Tyrosine Phosphatase Profiling Analysis of HIB-1B Cells during Brown Adipogenesis / Journal of Microbiology and Biotechnology 22 (7) : 1029
Cypess, A. M. / 2009 / Identification and importance of brown adipose tissue in adult humans / N. Engl. J. Med. 360 : 1509 ~ 1517
Farmer, S. R. / 2009 / Obesity: be cool, lose weight / Nature 458 : 839 ~ 840
Goldstein, B. J. / 1993 / Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation / Receptor 3 : 1 ~ 15
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