지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 139 - 148 (10page)
이용수
초록· 키워드
오류제보하기
In the past decade, the incidence of type 2 diabetes (T2D) has rapidly increased, along with the associated cardiovascular complications. Therefore, understanding the pathophysiology underlying T2D, the associated complications and the impact of therapeutics on the T2D development has critical importance for current and future therapeutics. The prevailing feature of T2D is hyperglycemia due to excessive hepatic glucose production, insulin resistance, and insufficient secretion of insulin by the pancreas. These contribute to increased fatty acid influx into the liver and muscle causing accumulation of lipid metabolites. These lipid metabolites cause dyslipidemia and non-alcoholic fatty liver disease, which ultimately contributes to the increased cardiovascular risk in T2D. Therefore, understanding the mechanisms of hepatic insulin resistance and the specific role of liver lipids is critical in selecting and designing the most effective therapeutics for T2D and the associated co-morbidities, including dyslipidemia and cardiovascular disease. Herein, we review the effects and molecular mechanisms of conventional anti-hyperglycemic and lipid-lowering drugs on glucose and lipid metabolism.
목차
등록된 정보가 없습니다.
참고문헌 (112)
참고문헌 신청
Zimmet P / 2001 / Global, societal implications of the diabetes epidemic / Nature 414:782~787
Guariguata L / 2013 / Global estimates of diabetes prevalence for 2013, projections for 2035 / Diabetes Res Clin Pract 103:137~149
Roger VL / 2012 / Heart disease, stroke statistics--2012 update: a report from the American Heart Association / Circulation 125:e2~e220
UK Prospective Diabetes Study(UKPDS)Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment, risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
Bonora E / 2002 / HOMAestimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study / Diabetes Care 25:1135~1141
Guariguata L / 2013 / Global estimates of diabetes prevalence for 2013, projections for 2035 / Diabetes Res Clin Pract 103:137~149
Roger VL / 2012 / Heart disease, stroke statistics--2012 update: a report from the American Heart Association / Circulation 125:e2~e220
UK Prospective Diabetes Study(UKPDS)Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment, risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
Bonora E / 2002 / HOMAestimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study / Diabetes Care 25:1135~1141
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The implications of signaling lipids in cancer metastasis
Experimental and Molecular Medicine
2018 .01
-
Chain Flexibility of Medicinal Lipids Determines Their Selective Partitioning into Lipid Droplets
한국생물공학회 학술대회
2023 .10
-
Lipid Conjugates for Artificial Lipid Membranes
한국생물공학회 학술대회
2022 .04
-
Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Experimental and Molecular Medicine
2023 .05
-
Development of RNA Therapeutics and Lipid Nanoparticle Formulation for In vivo Delivery
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
Lipid content and fatty acid composition of Chlamydomonas reinhardtii under nutrient limitation condition
한국생물공학회 학술대회
2016 .10
-
Lipid-based Particles with Specific Macrophage Accumulation Capability for the Treatment of Inflammatory Diseases
한국생물공학회 학술대회
2022 .09
-
Use of in vivo magnetic resonance spectroscopy for studying metabolic diseases
Experimental and Molecular Medicine
2015 .01
-
Investigating Lysozyme-Lipid Interactions for Improved Tear Film Lipid Layer Functionality
한국생물공학회 학술대회
2023 .04
-
Development of Next Generation Lipid Nanoparticle for mRNA Delivery
한국생물공학회 학술대회
2023 .04
-
Enhancing Biodiesel Production from Microalgae and Sewage Sludge Lipids by Adding Waste Coffee Ground Lipids
KSBB Journal
2023 .09
-
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
Experimental and Molecular Medicine
2021 .11
-
Use of Magnetic Nanoparticle to Improve Lipid Production
한국생물공학회 학술대회
2017 .04
-
Cultivation process development for improvement of lipid productivity
한국생물공학회 학술대회
2018 .10
-
Lipid Based Drug Delivery System: Formulation Concept and Optimization Using Quality by Design
한국생물공학회 학술대회
2017 .10
-
A Novel mRNA Delivery System Using Self-Assembled Lipid Nanoparticles
한국생물공학회 학술대회
2022 .09
-
자색고구마 섭취와 유산소 복합운동이 비만 여중생의 건강체력, 혈중지질 및 인슐린 저항성에 미치는 영향
한국산학기술학회 논문지
2015 .11
-
Anti-inflammatory Effect of Yeast-based Lipid Extracts
한국생물공학회 학술대회
2015 .10
-
Effects of Lipid Packing on Lipid Flip-Flop Phenomena : A Neutron Reflectivity Study
한국고분자학회 학술대회 연구논문 초록집
2015 .10
-
Development of Safe and Efficient Lipid Nanoparticles (LNP) Including Biodegradable Ionizable Lipid
한국고분자학회 학술대회 연구논문 초록집
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0