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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 103 - 108 (6page)
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Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKL-induced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect. CORM-2 also inhibited RANKLinduced osteoclastogenesis and osteoclastic resorption activity in marrow-derived macrophages. Treatment with hemin, a HO-1 inducer, strongly inhibited RANKL-induced osteoclastogenesis in wild-type macrophages, but was ineffective in HO-1＋/- cells. CORM-2 reduced RANKL-induced NFATc1 expression by inhibiting IKK-dependent NF-κB activation and reactive oxygen species production. These results suggest that CO potently inhibits RANKL-induced osteoclastogenesis by inhibiting redox-sensitive NF-κB-mediated NFATc1 expression. Our findings indicate that HO-1/CO can act as an antiresorption agent and reduce bone loss by blocking osteoclast differentiation.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Asagiri M / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis / J Exp Med 202 : 1261 ~ 1269
Asagiri M and Takayanagi H / 2007 / The molecular understanding of osteoclast differentiation / Bone 40 : 251 ~ 264
Ayer A / 2016 / Heme oxygenases in cardiovascular health and disease / Physiol Rev 96 : 1449 ~ 1508
Boyce BF / 2013 / Advances in the regulation of osteoclasts and osteoclast functions / J Dent Res 92 : 860 ~ 867
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
Asagiri M and Takayanagi H / 2007 / The molecular understanding of osteoclast differentiation / Bone 40 : 251 ~ 264
Ayer A / 2016 / Heme oxygenases in cardiovascular health and disease / Physiol Rev 96 : 1449 ~ 1508
Boyce BF / 2013 / Advances in the regulation of osteoclasts and osteoclast functions / J Dent Res 92 : 860 ~ 867
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
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