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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 79 - 84 (6page)
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Emphysema, a pathologic component of the chronic obstructive pulmonary disease, causes irreversible destruction of lung. Many researchers have reported that mesenchymal stem cells can regenerate lung tissue after emphysema. We evaluated if spheroid human adipose-derived mesenchymal stem cells (ASCs) showed greater regenerative effects than dissociated ASCs in mice with elastase-induced emphysema. ASCs were administered via an intrapleural route. Mice injected with spheroid ASCs showed improved regeneration of lung tissues, increased expression of growth factors such as fibroblast growth factor-2 (FGF2) and hepatocyte growth factor (HGF), and a reduction in proteases with an induction of protease inhibitors when compared with mice injected with dissociated ASCs. Our findings indicate that spheroid ASCs show better regeneration of lung tissues than dissociated ACSs in mice with elastase-induced emphysema.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bartosh TJ / 2010 / Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their anti-inflammatory properties / Proc Natl Acad Sci U S A 107 : 1372
Bates RC / 1994 / Apoptosis induced by inhibition of intercellular contact / J Cell Biol 125 : 403 ~ 415
Cheng NC / 2012 / The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities / Biomaterials 33 :
Churg A / 2012 / Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD / Eur Respir J 39 : 197 ~ 209
Guan XJ / 2013 / Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors / J Cell Biochem 114 : 323 ~ 335
Bates RC / 1994 / Apoptosis induced by inhibition of intercellular contact / J Cell Biol 125 : 403 ~ 415
Cheng NC / 2012 / The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities / Biomaterials 33 :
Churg A / 2012 / Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD / Eur Respir J 39 : 197 ~ 209
Guan XJ / 2013 / Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors / J Cell Biochem 114 : 323 ~ 335
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