지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 165 - 169 (5page)
이용수
초록· 키워드
오류제보하기
Excess free iron generates oxidative stress that may contribute to the pathogenesis of various causes of neurodegenerative diseases. In this study, we assessed the modification of ferritin induced by H₂O₂. When ferritin was incubated with H₂O₂, the degradation of ferritin L-chain increased with the H₂O₂concentration whereas ferritin H-chain was remained. Free radical scavengers, azide, thiourea, and N-acetyl-L-cysteine suppressed the H₂O₂-mediated ferritin modification. The iron specific chelator,deferoxamine, effectively prevented H₂O₂-mediated ferritin degradation in modified ferritin. The release of iron ions from ferritin was increased in H₂O₂concentration-dependent manner. The present results suggest that free radicals may play a role in the modification and iron releasing of ferritin by H₂O₂. It is assumed that oxidative damage of ferritin by H₂O₂may induce the increase of iron content in cells and subsequently lead to the deleterious condition. [BMB reports 2011; 44(3): 165-169]
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Davies, K. J / 1987 / Protein damage and degradation by oxygen radicals. II. Modification of amino acids / J. Biol. Chem 262 : 9902 ~ 9907
Double, K. L / 1998 / In vitro studies of ferritin iron release and neurotoxicity / J. Neurochem 70 : 2492 ~ 2499
Flaherty, J. T / 1988 / Reperfusion injury / Free Radic. Biol. Med 5 : 409 ~ 419
Galaris, D / 2008 / Oxidative stress and iron homeostasis: mechanistic and health aspects / Crit. Rev. Clin. Lab. Sci 45 : 1 ~ 23
Galkina, E / 2009 / Immune and inflammatory mechanisms of atherosclerosis / Annu. Rev. Immunol 27 : 165 ~ 197
Double, K. L / 1998 / In vitro studies of ferritin iron release and neurotoxicity / J. Neurochem 70 : 2492 ~ 2499
Flaherty, J. T / 1988 / Reperfusion injury / Free Radic. Biol. Med 5 : 409 ~ 419
Galaris, D / 2008 / Oxidative stress and iron homeostasis: mechanistic and health aspects / Crit. Rev. Clin. Lab. Sci 45 : 1 ~ 23
Galkina, E / 2009 / Immune and inflammatory mechanisms of atherosclerosis / Annu. Rev. Immunol 27 : 165 ~ 197
이 논문의 저자 정보
최근 본 자료
댓글(0)
0