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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 431 - 436 (6page)
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Human papillomavirus (HPV) is the major cause of cervical cancer, a deadly threat to millions of females. The early oncogene product (E7) of the high-risk HPV16 is the primary agent associated with HPV-related cervical cancers. In order to understand how E7 contributes to the transforming activity, we investigated the structural features of the flexible N-terminal region (46 residues) of E7 by carrying out N-15 heteronuclear NMR experiments and replica exchange molecular dynamics simulations. Several NMR parameters as well as simulation ensemble structures indicate that this intrinsically disordered region of E7 contains two transient (10-20% populated) helical pre-structured motifs that overlap with important target binding moieties such as an E2F-mimic motif and a pRb-binding LXCXE segment. Presence of such target-binding motifs in HPV16 E7 provides a reasonable explanation for its promiscuous target-binding behavior associated with its transforming activity.
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참고문헌 (39)
참고문헌 신청
Frazer I / 2002 / Vaccines for papillomavirus infection / Virus Res 89:271~274
Roman A / 2013 / The papillomavirus E7proteins / Virology 445:138~168
McLaughlin-Drubin ME / 2012 / Cancer associated human papillomaviruses / Curr Opin Virol 2:459~466
Chemes LB / 2012 / Evolution of linear motifs within the papillomavirus E7 oncoprotein / J Mol Biol 422:336~346
Munger K / 2001 / Biological activities and molecular targets of the human papillomavirus E7 oncoprotein / Oncogene 20:7888~7898
Roman A / 2013 / The papillomavirus E7proteins / Virology 445:138~168
McLaughlin-Drubin ME / 2012 / Cancer associated human papillomaviruses / Curr Opin Virol 2:459~466
Chemes LB / 2012 / Evolution of linear motifs within the papillomavirus E7 oncoprotein / J Mol Biol 422:336~346
Munger K / 2001 / Biological activities and molecular targets of the human papillomavirus E7 oncoprotein / Oncogene 20:7888~7898
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