지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 532 - 537 (6page)
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초록· 키워드
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P18, a member of the INK4 family of cyclin-dependent kinase inhibitors, is a tumor suppressor protein and plays a key cell survival role in a variety of human cancers. Under pathophysiological conditions, the INK4 group proteins participate in novel biological functions associated with neuronal diseases and oxidative stress. Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons, and oxidative stress is important in its pathogenesis. Therefore, we examined the effects of PEP-1-p18 on oxidative stress-induced SH-SY5Y cells and in a PD mouse model.
The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenyl pyridinium-induced SH-SY5Y cell death by inhibiting Bax expression levels and DNA fragmentation. Additionally, PEP-1-p18prevented dopaminergic neuronal cell death in the substantia nigra of a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PD mouse model. These results indicate that PEP-1-p18 may be a useful therapeutic agent against various diseases and is a potential tool for treating PD. [BMB Reports 2012; 45(9): 532-537]
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ahn, E. H. / 2010 / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice / TOXICOLOGY 276 : 192 ~ 197
An, J. J. / 2008 / Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult / FEBS JOURNAL 275 : 1296 ~ 1308
Choi, H. S. / 2006 / PEP-1-SOD fusion protein efficiently protects against paraquat-induced doparninergic neuron damage in a Parkinson disease mouse model / FREE RADICAL BIO
Dauer, W. / 2003 / Parkinson’s disease: mechanisms and models / Neuron 39 : 889 ~ 909
Dawson, T. M. / 2003 / Molecular pathways of neurodegeneration in Parkinson’s disease / Science 302 : 819 ~ 822
An, J. J. / 2008 / Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult / FEBS JOURNAL 275 : 1296 ~ 1308
Choi, H. S. / 2006 / PEP-1-SOD fusion protein efficiently protects against paraquat-induced doparninergic neuron damage in a Parkinson disease mouse model / FREE RADICAL BIO
Dauer, W. / 2003 / Parkinson’s disease: mechanisms and models / Neuron 39 : 889 ~ 909
Dawson, T. M. / 2003 / Molecular pathways of neurodegeneration in Parkinson’s disease / Science 302 : 819 ~ 822
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