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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 599 - 608 (10page)
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As the prevalence of obesity has increased explosively overthe last several decades, associated metabolic disorders,including type 2 diabetes, dyslipidemia, hypertension, andcardiovascular diseases, have been also increased. Thus, newstrategies for preventing and treating them are needed. Thenuclear peroxisome proliferator-activated receptors (PPARs)are involved fundamentally in regulating energy homeostasis;thus, they have been considered attractive drug targets foraddressing metabolic disorders. Among the PPARs, PPARγ is amaster regulator of gene expression for metabolism,inflammation, and other pathways in many cell types,especially adipocytes. It is a physiological receptor of thepotent anti-diabetic drugs of the thiazolidinediones (TZDs)class, including rosiglitazone (Avandia). However, TZDs haveundesirable and severe side effects, such as weight gain, fluidretention, and cardiovascular dysfunction. Recently, manyreports have suggested that PPARγ could be modulated bypost-translational modifications (PTMs), and modulation ofPTM has been considered as novel approaches for treatingmetabolic disorders with fewer side effects than the TZDs. Inthis review, we discuss how PTM of PPARγ may be regulatedand issues to be considered in making novel anti-diabeticdrugs that can modulate the PTM of PPARγ.
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참고문헌 (23)
참고문헌 신청
Barak, Y. / 1999 / PPAR gamma is required for placental, cardiac, and adipose tissue development / Mol. Cell 4 : 585 ~ 595
Barroso, I. / 1999 / Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension / Nature 402 : 880 ~ 883
Berger, J. / 2000 / A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus / Mol. Cell. Endocrinol 162 : 57 ~ 67
Chawla, A. / 2001 / Nuclear receptors and lipid physiology: opening the X-files / Science 5548 : 1688 ~ 1670
Dreyer, C. / 1992 / Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors / Cell 68 : 879 ~ 887
Barroso, I. / 1999 / Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension / Nature 402 : 880 ~ 883
Berger, J. / 2000 / A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus / Mol. Cell. Endocrinol 162 : 57 ~ 67
Chawla, A. / 2001 / Nuclear receptors and lipid physiology: opening the X-files / Science 5548 : 1688 ~ 1670
Dreyer, C. / 1992 / Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors / Cell 68 : 879 ~ 887
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