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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 81 - 92 (12page)
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Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.
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참고문헌 (207)
참고문헌 신청
Lee Y / 2015 / Aging Mechanisms / Springer Japan :123~169
Giannakou ME / 2007 / Role of insulin-like signalling in Drosophila lifespan / Trends Biochem Sci 32:180~188
Fontana L / 2010 / Extending healthy life span--from yeast to humans / Science 328:321~326
Kenyon CJ / 2010 / The genetics of ageing / Nature 464:504~512
Morris JZ / 1996 / A phosphatidylinositol-3-OH kinase family member regulating longevity, diapause in Caenorhabditis elegans / Nature 382:536~539
Giannakou ME / 2007 / Role of insulin-like signalling in Drosophila lifespan / Trends Biochem Sci 32:180~188
Fontana L / 2010 / Extending healthy life span--from yeast to humans / Science 328:321~326
Kenyon CJ / 2010 / The genetics of ageing / Nature 464:504~512
Morris JZ / 1996 / A phosphatidylinositol-3-OH kinase family member regulating longevity, diapause in Caenorhabditis elegans / Nature 382:536~539
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