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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 262 - 266 (5page)
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초록· 키워드
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The aac(6')-Ib gene is the most prevalent gene that encodes aminoglycoside-modifying enzymes and confers resistance to tobramycin, kanamycin, and amikacin. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. Two main methods, sequence analysis and the restriction enzyme method, can detect the aac(6')-Ib-cr variant in clinical strains. We collected the 85strains that were believed to be aac(6')-Ib positive from clinical isolates. Among them, 38 strains were the wild-type; the remaining 47 strains were the aac(6')-Ib-cr variant. Of these 47strains, 19 simultaneously harbored aac(6')-Ib and aac(6')-Ibcr.
Our study aims to report the characteristics of the 19 strains that simultaneously harbored both genes. This study is the first investigation published in Korea of strains that included both aac(6')-Ib and aac(6')-Ib-cr variant. [BMB reports 2011; 44(4):262-266]
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참고문헌 (21)
참고문헌 신청
Bell, J. M / 2010 / aac(6')- Ib-cr genotyping by simultaneous high resolution melting analysis of an unlabelled probe and full length amplicon. / Antimicrob. Agents Chemothe
Clinical and Laboratory Standards Instit / 2008 / Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement
Deborah, J. E / 2002 / Detection of gyrA mutations in quinolone-resistant Salmonella enterica by denaturing high-performance liquid chromatography / J. Clin. Microbiol 40 :
Florez, A. B / 2007 / Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes / Int.
Guillard, T / 2009 / Rapid detection of quinolone resistance gene aac(6')-Ib-cr by pyrosequencing / J. Clin. Microbiol 48 : 286 ~ 289
Clinical and Laboratory Standards Instit / 2008 / Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement
Deborah, J. E / 2002 / Detection of gyrA mutations in quinolone-resistant Salmonella enterica by denaturing high-performance liquid chromatography / J. Clin. Microbiol 40 :
Florez, A. B / 2007 / Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes / Int.
Guillard, T / 2009 / Rapid detection of quinolone resistance gene aac(6')-Ib-cr by pyrosequencing / J. Clin. Microbiol 48 : 286 ~ 289
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