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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 452 - 457 (6page)
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The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), ERα and ERβ. ERα-induced Egr-1 expression has been extensively studied; however, the role of ERβ is yet not known. In the present study, we investigated whether or not ERβ induces Egr-1 expression in C6 rat glioma cells, which express ERβ but not ERα. Our results show that ERβ promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.
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참고문헌 (23)
참고문헌 신청
Aicher, W. K / 1999 / Analysis of functional elements in the human Egr-1 gene promoter / Rheumatol. Int 18 : 207 ~ 214
Chen, C. C / 2004 / Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen- activated protein kinase-dependent phosphorylation of ELK-1 / J. Cell. Biochem 93 : 1063
Czlonkowska, A / 2003 / Influence of estrogens on neurodegenerative processes / Med. Sci. Monit 9 : RA247 ~ RA256
Duan, R / 2001 / Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1 / J. Biol. Chem 276 : 1159
Edwards, S. A / 1991 / The transcription factor, Egr-1, is rapidly modulated in response to retinoic acid in P19 embryonal carcinoma cells / Dev. Biol 148 : 165 ~ 173
Chen, C. C / 2004 / Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen- activated protein kinase-dependent phosphorylation of ELK-1 / J. Cell. Biochem 93 : 1063
Czlonkowska, A / 2003 / Influence of estrogens on neurodegenerative processes / Med. Sci. Monit 9 : RA247 ~ RA256
Duan, R / 2001 / Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1 / J. Biol. Chem 276 : 1159
Edwards, S. A / 1991 / The transcription factor, Egr-1, is rapidly modulated in response to retinoic acid in P19 embryonal carcinoma cells / Dev. Biol 148 : 165 ~ 173
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