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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 571 - 576 (6page)
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Radiotherapy is considered to cause detrimental effects on bone tissue eventually increasing bone loss and fracture risk. However,there is a great controversy on the real effects of irradiation itself on osteoblasts, and the mechanisms by which irradiation affects osteoblast differentiation and mineralization are not completely understood. We explored how X-ray radiation influences differentiation and bone-specific gene expression in mouse calvarial osteoblasts. Irradiation at 2 Gy not only increased differentiation and mineralization of the cells, but also upregulated the expression of alkaline phosphatase, type I collagen, osteopontin,and osteocalcin at early stages of differentiation. However, irradiation at higher doses (＞2 Gy) did not stimulate osteoblast differentiation,rather it suppressed DNA synthesis by the cells without a toxic effect. Additional experiments suggested that transforming growth factor-beta 1 and runt-transcription factor 2 play important roles in irradiation- stimulated bone differentiation by acting as upstream regulators of bone-specific markers. [BMB Reports 2012;45(10): 571-576]
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참고문헌 (23)
참고문헌 신청
Camozzi, V. / 2007 / Role of biochemical markers of bone remodeling in clinical practice / J. Endocrinol. Invest. 30 : 13 ~ 17
Chae, H. J. / 1999 / Effect of ionizing radiation on the differentiation of ROS 17/2.8 osteoblasts through free radicals / J. Radiat. Res. 40 : 323 ~ 335
Choi, J. Y. / 1996 / Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells / J. Cell Biochem. 61 : 609 ~ 618
Dare, A. / 1997 / Effects of ionizing radiation on proliferation and differentiation of osteoblast-like cells / J. Dent. Res. 76 : 658 ~ 664
Delanian, S. / 2005 / Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis / J. Clin.
Chae, H. J. / 1999 / Effect of ionizing radiation on the differentiation of ROS 17/2.8 osteoblasts through free radicals / J. Radiat. Res. 40 : 323 ~ 335
Choi, J. Y. / 1996 / Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells / J. Cell Biochem. 61 : 609 ~ 618
Dare, A. / 1997 / Effects of ionizing radiation on proliferation and differentiation of osteoblast-like cells / J. Dent. Res. 76 : 658 ~ 664
Delanian, S. / 2005 / Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis / J. Clin.
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