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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 520 - 525 (6page)
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초록· 키워드
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Cardiovascular diseases arising from atherosclerosis are the leading causes of mortality and morbidity worldwide. Lipid-lowering agents have been developed in order to treat hypercholesterolemia, a major risk factor for atherosclerosis. However, the prevalence of cardiovascular diseases is increasing, indicating a need to identify novel therapeutic targets and develop new treatment agents. Adenosine receptors (ARs) are emerging as therapeutic targets in asthma, rheumatoid arthritis, cancer, ischemia, and inflammatory diseases. This study assessed whether LJ-1888, a selective antagonist for A3 AR, can inhibit the development of atherosclerosis in apolipoprotein E knock-out (ApoE−/−) mice who are fed a western diet. Plaque formation was significantly lower in ApoE−/− mice administered LJ-1888 than in mice not administered LJ-1888, without any associated liver damage. LJ-1888 treatment of ApoE−/− mice prevented western diet-induced hypercholesterolemia by markedly reducing low-density lipoprotein cholesterol levels and significantly increasing high-density lipoprotein cholesterol concentrations. Reduced hypercholesterolemia in ApoE−/− mice administered LJ-1888 was associated with the enhanced expression of genes involved in bile acid biosynthesis. These findings indicate that LJ-1888, a selective antagonist for A3 AR, may be a novel candidate for the treatment of atherosclerosis and hypercholesterolemia.
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등록된 정보가 없습니다.
참고문헌 (3)
참고문헌 신청
정세진 / 2017 / The Role of Macrophage Lipophagy in Reverse Cholesterol Transport / Endocrinology and Metabolism 32(1):41~46
박현주 / 2017 / Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and -9 / BMB Reports 50(12):628~633
정혜진 / 2017 / Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells / BMB Reports 50(6):323~328
박현주 / 2017 / Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and -9 / BMB Reports 50(12):628~633
정혜진 / 2017 / Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells / BMB Reports 50(6):323~328
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