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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 262 - 268 (7page)
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초록· 키워드
오류제보하기
Antibodies are powerful and versatile tools to play a critical role in the diagnosis and treatment of many diseases. Their application has been enhanced significantly with the advanced recombinant DNA and heterologonous expression technologies, allowing to produce munotherapeutic proteins with improved biofunctional properties. However, with currently available technologies, mammalian cell-based therapeutic antibody production, as an alternative for production in humans and animals, is often not plentiful for passive immunotherapeutics in treatment of many diseases. Recently, plant expression systems for therapeutic antibodies have become well-established. Thus, plants have been considered to provide an attractive alternative production system for therapeutic antibodies, as plants have several advantages such as the lack of human pathogens, and low cost of upstream production and flexible scale-up of highly valuable recombinant glycoproteins. Recent advances in modification of posttranslational processing for human-like glycosylation in transgenic plants will make it possible that plant can become a suitable protein expression system over the animal cellbased current production system. This review will discuss recent advances in plant expression technology and issues for their application to therapeutic antibody production.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Armour, KL / 1999 / Recombinant human IgG molecules lacking Fc-gamma Receptor I binding and monocyte triggering activities / Eur J Immunol 29 : 2613 ~ 2624
Ashford DA / 1987 / The β -1→2-D-xylose and α-1→3-L-fucose substituted N-linked oligosaccharides from Erythrina cristagalli lectin / Eur J Biochem 166 : 311 ~ 320
Bakker H / 2001 / Galactose-extended glycans of antibodies produced by transgenic plants / Proc Natl Acad Sci USA : 2899 ~ 2904
Balen B / 2006 / Glycoproteomic survey of Mammillaria gracillis tissues grown in vitro / J Proteome Res 5 : 1658 ~ 1666
Breedveld FC / 2000 / Therapeutic monoclonal antibodies / Lancet 355 : 735 ~ 740
Ashford DA / 1987 / The β -1→2-D-xylose and α-1→3-L-fucose substituted N-linked oligosaccharides from Erythrina cristagalli lectin / Eur J Biochem 166 : 311 ~ 320
Bakker H / 2001 / Galactose-extended glycans of antibodies produced by transgenic plants / Proc Natl Acad Sci USA : 2899 ~ 2904
Balen B / 2006 / Glycoproteomic survey of Mammillaria gracillis tissues grown in vitro / J Proteome Res 5 : 1658 ~ 1666
Breedveld FC / 2000 / Therapeutic monoclonal antibodies / Lancet 355 : 735 ~ 740
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