지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 358 - 366 (9page)
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초록· 키워드
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Background: Metabolic syndrome has been reported to have adverse effects on cognitive function, although the results are confl icting. The purpose of this study was to examine the relationship between metabolic syndrome and cognitive function in elderly Korean participants older than 60 years.
Methods: We examined elderly participants who visited the health promotion center in Gyeonggi-do province. We categorized the participants into two groups based on the presence of metabolic syndrome (48 participants in the metabolic syndrome group and 45 in the control group). Cognitive function was assessed in all participants using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K).
Results: Compared with those without metabolic syndrome, participants with metabolic syndrome had lower mean total CERAD-K scores (64.2 ± 11.1 vs. 69.8 ± 9.2, P = 0.010). In the comparison of CERAD-K items, signifi cantly lower scores were observed in the verbal fl uency test, the construction recall test, the word list learning test, and trail making B in the group with metabolic syndrome. After controlling age, sex, education, smoking, alcohol, physical activity and the Korean version of the Short Geriatric Depression Scale of Korean, multiple regression analysis showed that metabolic syndrome was independently associated with cognitive function (P = 0.014). Alcohol intake (P = 0.002) and education years (P = 0.001)were also contributing factors to cognitive function.
Conclusion: This study found a signifi cant relationship between cognitive function and metabolic syndrome. It will be necessary to perform a prospective study to determine whether metabolic syndrome causes cognitive dysfunction or if the correction of metabolic syndrome can improve cognitive function.
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참고문헌 (23)
참고문헌 신청
/ 2001 / Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Educatio
Akomolafe A / 2006 / Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study / Arch Neurol 63 : 1551 ~ 1555
Bae JN / 2004 / Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients / J Psychosom Res 57 : 297 ~ 305
Chandler MJ / 2005 / A total score for the CERAD neuropsychological battery / Neurology 65 : 102 ~ 106
Hayden KM / 2006 / Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study / Alzheimer Dis Assoc Disord 20 : 93 ~ 100
Akomolafe A / 2006 / Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study / Arch Neurol 63 : 1551 ~ 1555
Bae JN / 2004 / Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients / J Psychosom Res 57 : 297 ~ 305
Chandler MJ / 2005 / A total score for the CERAD neuropsychological battery / Neurology 65 : 102 ~ 106
Hayden KM / 2006 / Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study / Alzheimer Dis Assoc Disord 20 : 93 ~ 100
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