지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 275 - 281 (7page)
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초록· 키워드
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Background: Local epidemiologic data on prevalent pathogens are important to guide empirical antibiotic therapy. In this study, we observed annual changes in frequency of occurrence and in vitro antimicrobial susceptibility of blood isolates over a period of 13 years.
Materials and Methods: We reviewed blood isolates identified during the period from 1998 to 2010 at Seoul National University Hospital. Only first isolates for each patient were included in the analysis. We analyzed the frequency of isolates and their trend with regard to in vitro antimicrobial susceptibility. Data were presented according to guidelines of the Clinical and Laboratory Standards Institute (CLSI) (2009).
Results: A total of 23,501 isolates were identified during the period from 1998 to 2010.
Fifty-five percent of the isolates were gram-positive cocci, 38% were gram-negative rods,and 3% were fungi. Coagulase-negative Staphylococcus (CoNS) (24%), Escherichia coli (16%), Staphylococcus aureus (10%), and Klebsiella pneumoniae (8%) were the most commonly isolated bacteria, and Candida albicans (2%) was the most commonly isolated fungus. The frequency of CoNS increased from 18.0% to 26.8%,whereas the frequency of E. coli and K. pneumoniae decreased from 20.2% to 13.7%and from 11.7% to 6.7%, respectively. Overall, the proportion of methicillin-resistant S. aureus changed from 47.9% to 62.1%. In E. coli, the resistance rate of cefotaxime and ciprofloxacin increased over a period of 13 years. However, such an increase of resistance was not observed in K. pneumoniae. In P. aeruginosa , and particularly in A.
baumannii , resistance to imipenem rose alarmingly (3% in 1998 to 27.8% in 2010, 5% in 1998 to 68.9% in 2010, respectively).
Conclusions: Over the last 13 years, the proportion of CoNS in blood isolates increased,which led to a relative decrease of isolated gram-negative rods. Proportions of MRSA showed no significant change, whereas cefotaxime resistant and ciprofloxacin resistant E.
coli increased. Imipenem resistant P. aeruginosa and A. baumannii also increased during the study period.
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참고문헌 (22)
참고문헌 신청
Arpi M. / 1994 / Changing etiology of bacteremia in patients with hematological malignancies in Denmark / Scand J Infect Dis 26 : 157 ~ 162
Asensio A. / 2011 / Trends in yearly prevalence of third-generation cephalosporin and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish
Biedenbach DJ. / 2004 / Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program(19
CLSI. / 2009 / Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data; Approved Guideline - Third Edition / M39-A3 29
CLSI. / 2011 / Performance Standards for Antimicrobial Susceptibility Testing; Twenty-First Informational Supplement / M100- S21 31
Asensio A. / 2011 / Trends in yearly prevalence of third-generation cephalosporin and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish
Biedenbach DJ. / 2004 / Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program(19
CLSI. / 2009 / Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data; Approved Guideline - Third Edition / M39-A3 29
CLSI. / 2011 / Performance Standards for Antimicrobial Susceptibility Testing; Twenty-First Informational Supplement / M100- S21 31
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