지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 426 - 430 (5page)
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초록· 키워드
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Background: Nasopharyngeal bacterial flora can cause respiratory tract diseases as well as invasive bacterial diseases. Moraxella catarrhalis colonizing in the nasopharynx is considered an important potential pathogen with an increasing production of β-lactamase. This study examined the nasopharyngeal colonization rate of M. catarrhalis and the antibiotic susceptibility of M. catarrhalis .
Materials and Methods: Healthy children who visited one of the three University hospitals in the Republic of Korea or attended a day-care center around the participating hospitals were enrolled in this study. The nasopharyngeal samples were obtained by nasopharyngeal washing with normal saline and M. catarrhalis was isolated. The nasopharyngeal colonization rate of M. catarrhalis was investigated and the minimal inhibitory concentrations (MICs) were measured for commonly used oral antibiotics (amoxicillin, amoxicillin/clavulanate, cefaclor, cefixime, cefdinir,cefditoren, erythromycin and trimethoprim).
Results: Three hundred and seventy-nine children aged between 6 months and 5years were enrolled, and the nasopharyngeal colonization rate of M. catarrhalis was 33% (124 children). All isolated M. catarrhalis produced β-lactamase. The MIC90 of the antibiotics were as follows: amoxicillin, >16 mg/L; amoxicillin/clavulanate, 0.5mg/L; cefaclor, 8 mg/L ; cefixime, 0.125 mg/L; cefdinir, 0.25 mg/L; cefditoren, 0.25mg/L; erythromycin, 0.5 mg/L; and trimethoprim, >16 mg/L.
Conclusions: M. catarrhalis was colonized in 33% of the children aged 6 months to 5 years, and showed low MICs for amoxicillin/clavulanate and oral 2nd and 3rd generation cephalosporins.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Gunnarsson RK. / 1998 / The prevalence of potential pathogenic bacteria in nasopharyngeal samples from healthy children and adults / Scand J Prim Health Care 16:13~17
van Gils EJ. / 2011 / Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial / Vaccine 29:7595~7598
Jourdain S. / 2011 / Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins / Clin Microbiol Infect 17:907~914
Pingault NM. / 2010 / Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie-Boulder, Western Australia / Pathology 42:273~279
Harrison CJ. / 2009 / Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics / J Antimicrob Chemother 63:511~519
van Gils EJ. / 2011 / Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial / Vaccine 29:7595~7598
Jourdain S. / 2011 / Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins / Clin Microbiol Infect 17:907~914
Pingault NM. / 2010 / Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie-Boulder, Western Australia / Pathology 42:273~279
Harrison CJ. / 2009 / Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics / J Antimicrob Chemother 63:511~519
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