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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 37 - 41 (5page)
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Pancreatic acinar cells exhibit a polarity that is characterized by the localization of secretory granules at the apical membrane. However, the factors that regulate cellular polarity in these cells are not well understood. In this study,we investigated the effect of Mist1, a basic helix-loop-helix transcription factor, on the cellular architecture of pancreatic acinar cells. Mist1-null mice displayed secretory granules that were diffuse throughout the pancreatic acinar cells, from the apical to basolateral membranes, whereas Mist1heterozygote mice showed apical localization of secretory granules. Deletion of the Mist1 gene decreased the expression of type 3 inositol 1,4,5-triphosphate receptors (IP3R) but did not affect apical localization and expression of IP3R2. Mist1-null mice also displayed an increase in luminal areas and an increase in the expression of zymogen granules in pancreatic acinar cells. These results suggest that Mist1 plays a critical role in polar localization of cellular organelles and in maintaining cellular architecture in mouse pancreatic acinar cells.
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참고문헌 (17)
참고문헌 신청
Hankard R / 2002 / Nutrition and growth in cystic fibrosis / J. Horm Res 58 (suppl 1) : 16 ~ 20
Hong JH / 2003 / Scaffolding protein in Ca 2+ signaling / Int J Oral Biol 28 : 75 ~ 80
Krapp A / 1996 / The p48 subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helixloop- helix protein / EMBO J 15 (16) : 4317 ~ 4329
Krapp A / 1998 / The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas / Genes Dev 12 (23)
Lemercier C / 1997 / Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern / Dev Biol 182 (1) : 101 ~ 113
Hong JH / 2003 / Scaffolding protein in Ca 2+ signaling / Int J Oral Biol 28 : 75 ~ 80
Krapp A / 1996 / The p48 subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helixloop- helix protein / EMBO J 15 (16) : 4317 ~ 4329
Krapp A / 1998 / The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas / Genes Dev 12 (23)
Lemercier C / 1997 / Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern / Dev Biol 182 (1) : 101 ~ 113
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