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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 53 - 59 (7page)
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초록· 키워드
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Periodontal ligament (PDL) tissue is a connective tissue that is interposed between the roots of the teeth and the inner wall of the alveolar bone socket. PDL is always exposed to physiologic mechanical force such as masticatory force and PDL cells play important roles during orthodontic tooth movement by synthesizing and secreting different mediators involved in bone remodeling. The Wnt/β-catenin signaling pathway was recently shown to play a significant role in the control of bone formation. In the present study, we applied cyclic tensile stress of 20% elongation to cultured human PDL cells and assessed its impact after six days upon components of the Wnt/β-catenin signaling pathway. RTPCR analysis showed that Wnt1a, Wnt3a, Wnt10b and the Wnt receptor LRP5 were down-regulated, whereas the Wnt inhibitor DKK1 was up-regulated in response to these stress conditions. In contrast, little change was detected in the mRNA expression of Wnt5a, Wnt7b, Fz1, and LRP6. By western blotting we found decreased expression of the β- catenin and p-GSK-3β proteins. Our results thus show that mechanical stress suppresses the canonical Wnt/β-catenin signaling pathway in PDL cells.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Armstrong VJ / 2007 / Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to loadbearing and requires estrogen receptor alpha / J Biol Chem 28
Bain G / 2003 / Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction / Biochem Biophys Res Commu
Bartold PM / 2006 / Stem cells in the periodontal ligament / Periodontol. 2000 40 : 164 ~ 172
Basdra EK / 1997 / Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis / Eur J Orthod 19 : 615 ~ 621
Bellows CG / 1982 / Association between tension and orientation of periodontal ligament fibroblasts and exogenous collagen fibers in collagen gels in vitro / J Cell Sci 58 :
Bain G / 2003 / Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction / Biochem Biophys Res Commu
Bartold PM / 2006 / Stem cells in the periodontal ligament / Periodontol. 2000 40 : 164 ~ 172
Basdra EK / 1997 / Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis / Eur J Orthod 19 : 615 ~ 621
Bellows CG / 1982 / Association between tension and orientation of periodontal ligament fibroblasts and exogenous collagen fibers in collagen gels in vitro / J Cell Sci 58 :
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