지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
OSCC is currently the most common malignancy of the head and neck, affecting tens of thousands of patients per year worldwide. Natural flavonoids from plants are potential sources for novel anti-cancer drugs. Icariin is the active ingredient of flavonol glycoside, which is derived from the medical plant Herba Epimedii. A metabolite of icariin, icariside II exhibits a variety of pharmacological actions, including anti-rheumatic, anti-depressant, cardiovascular protective, and immunomodulatory functions. However, the exact mechanism causing the apoptosis-inducing effect of icariside II in OSCC is still not fully understood. In the present study, we assessed the anti-cancer effect of icariside II in OSCC cell lines by measuring its effect on cell viability, cell proliferation, and mitochondria membrane potential (MMP).
Icariside II treatment of OSCC cells resulted in a dose- and time-dependent decrease in cell viability. Hoechst staining indicated apoptosis in icariside II-treated HSC cells. Icariside II inhibited cell proliferation and induced apoptosis in HSC cells, with significant increases in all present parameters in HSC-4 cells. The results clearly suggested that icariside II induced apoptosis via activation of intrinsic pathways and caspase cascades in HSC-4 cell lines. The collective findings of the study suggested that Icariside II is a potential treatment for OSCC; in addition, the data could provide a basis for the development of a novel anti-cancer strategy.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Clayman GL / 1997 / Report of the Tenth International Symposium of the Foundation for Promotion of Cancer Research: Basic and clinical research in head and neck cancer / Japanese Journal of Clinical Oncology 27:361~368
Casiglia J / 2000 / A comprehensive review of oral cancer / General dentistry 49:72~82
R. Bryan Bell / 2007 / Tongue Cancer: Is There a Difference in Survival Compared With Other Subsites in the Oral Cavity? / Journal of Oral and Maxillofacial Surgery 65(2):229~236
Wen-Liang Lo / 2003 / Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival / Journal of Oral and Maxillofacial Surgery 61(7):751~758
Satoru Shintani / 2006 / Anti-tumor effect of radiation response by combined treatment with angiogenesis inhibitor, TNP-470, in oral squamous cell carcinoma / Oral Oncology 42(1):65~71
Casiglia J / 2000 / A comprehensive review of oral cancer / General dentistry 49:72~82
R. Bryan Bell / 2007 / Tongue Cancer: Is There a Difference in Survival Compared With Other Subsites in the Oral Cavity? / Journal of Oral and Maxillofacial Surgery 65(2):229~236
Wen-Liang Lo / 2003 / Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival / Journal of Oral and Maxillofacial Surgery 61(7):751~758
Satoru Shintani / 2006 / Anti-tumor effect of radiation response by combined treatment with angiogenesis inhibitor, TNP-470, in oral squamous cell carcinoma / Oral Oncology 42(1):65~71
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
사람구강편평상피암세포에서 유지놀에 의한 세포자멸사 유도 효과
한국치위생학회지
2015 .01
-
Gartanin Induces Apoptosis in Oral Squamous Cell Carcinoma Cell Lines through Mitochondrial Signaling Pathway
대한구강해부학회지
2015 .12
-
Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma
The Korean Journal of Physiology & Pharmacology
2024 .05
-
Oral squamous carcinoma cells stimulated by Porphyromonas gingivalis-derived lipopolysaccharide induce osteoclastogenesis through a paracrine mechanism
International Journal of Oral Biology
2024 .09
-
OSCC 세포에서 코디세핀이 유도하는 세포자멸사와 EMT 억제효과
한국구강보건과학회지
2022 .06
-
Effects of Sangju Honey on Oral Squamous Carcinoma Cells
대한암예방학회지
2022 .12
-
Methanol extracts of Sedum oryzifolium and its constituents, quercetin, attenuates the invasion of oral cancer cells through blocking Slug expression
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma
International Journal of Oral Biology
2019 .01
-
Salivary biomarkers in oral squamous cell carcinoma
대한구강악안면외과학회지
2020 .10
-
Efficacy of biological inhibitors in oral squamous cell carcinoma 3D culture models
International Journal of Oral Biology
2024 .03
-
Lipopeptides Extract from Bacillus Amyloliquefaciens Induce Human Oral Squamous Cancer Cell Death
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Flavonoid-induced apoptotic cell death in human cancer cells and itsmechanisms
Journal of Biomedical and Translational Research
2020 .01
-
Antitumor effect of E7080 in oral carcinoma xenograft model
Oral Biology Research
2016 .01
-
Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
대한구강악안면외과학회지
2022 .02
-
Mechanism Underlying Shikonin-induced Apoptosis and Cell Cycle Arrest on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line
International Journal of Oral Biology
2015 .01
-
Decreased expression of SOX7 correlates with vasculogenic mimicry and poor prognosis in oral squamous cell carcinoma
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Overall and disease-specific survival outcomes following primary surgery for oral squamous cell carcinoma: analysis of consecutive 67 patients
대한구강악안면외과학회지
2019 .01
-
Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Withaferin A as chemotherapeutic agent induced apoptosis in HSC-3 and HSC-4 cells
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Inhibitory Effects of Schisandra chinensis Seed Extracts on Breast Cancer
대한의생명과학회지
2025 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0